Institutionen för farmaci

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A S; Phillipson, Mia; Artursson, Per; Teleki, Alexandra

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease.

Kabedev, Aleksei; Hossain, Shakhawath; Hubert, Madlen; Larsson, Per; Bergström, Christel A.S.

Molecular Dynamics Simulations Reveal Membrane Interactions for Poorly Water-Soluble Drugs: Impact of Bile Solubilization and Drug Aggregation

Ibrahim, Moustafa M A; Redestad, Erik; Kjellsson, Maria C

Optimal Designs for Model-Based Assessment of Insulin Sensitivity and Glucose Effectiveness.

Svensson, Elin M

Probability of mycobactericidal activity of para-aminosalicylic acid with novel dosing regimens

Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E; Hooker, Andrew; Rostami-Hodjegan, Amin; Schmidt, Stephan; Suarez-Sharp, Sandra; Lukacova, Viera; Fang, Lanyan; Zhao, Liang

Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.

Ueckert, Sebastian; Karlsson, Mats

Improved numerical stability for the bounded integer model.

Arrington, Leticia; Ueckert, Sebastian; Ahamadi, Malidi; Macha, Sreeraj; Karlsson, Mats

Performance of longitudinal item response theory models in shortened or partial assessments.

Larsson, Per; Kabedev, Aleksei; Hossain, Md Shakhawath; Hubert, Madlen

Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z; Houston, J Brian; Kansy, Manfred; Kerns, Edward H; Lennernäs, Hans; Smith, Dennis A; Sugano, Kiyohiko

The Critical Role of Passive Permeability in Designing Successful Drugs

Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria; Ercan, Onur; Grinberga, Solveiga; Cao, Sha; Giachou, Paraskevi; Petersson, Anna; Tomczak, Magdalena; Urbas, Malgorzata; Zabicka, Dorota; Vingsbo Lundberg, Carina; Hughes, Diarmaid; Hobbie, Sven N; Friberg, Lena E

Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.

Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna; Shariatgorji, Reza; Haldimann, Klara; Platzack, Björn; Hughes, Diarmaid; Andrén, Per E; Böttger, Erik C; Friberg, Lena E; Hobbie, Sven N

Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.

Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan; Melhus, Håkan; Nielsen, Elisabet I.; Sulku, Johanna; Gillespie, Ulrika

Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.

Linnér, Love; Eriksson, Irene; Persson, Marie; Wettermark, Björn

Forecasting drug utilization and expenditure: ten years of experience in Stockholm.

Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J.; Camara, Miguel; Bergström, Christel

Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions

Nyman, Elin; Lindh, Maria; Lövfors, William; Simonsson, Christian; Persson, Alexander; Eklund, Daniel; Bäckström, Erica; Fridén, Markus; Cedersund, Gunnar

Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling.

Druedahl, Louise C.; Almarsdottir, Anna Birna; Kälvemark Sporrong, Sofia; De Bruin, Marie Louise; Hoogland, Hans; Minssen, Timo; van de Weert, Marco; Kesselheim, Aaron S.; Sarpatwari, Ameet

A qualitative study of biosimilar manufacturer and regulator perceptions on intellectual property and abbreviated approval pathways

Schmidt-Mende, Katharina; Andersen, Morten; Wettermark, Björn; Hasselstrom, Jan

Drug-disease interactions in Swedish senior primary care patients were dominated by non-steroid anti-inflammatory drugs and hypertension - a population-based registry study

Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran; Soderhall, Arvid; Hellström, Per M.; Lennernäs, Hans

Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

Ravandeh, M.; Kahlert, H.; Jablonowski, H.; Lackmann, J. -W; Striesow, J.; Agmo Hernández, Víctor; Wende, K.

A combination of electrochemistry and mass spectrometry to monitor the interaction of reactive species with supported lipid bilayers

Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Hansson, Per

Volume Transition and Phase Coexistence in Polyelectrolyte Gels Interacting with Amphiphiles and Proteins

Ekheden, Isabella; Ebrahim, Fereshte; olafsdottir, Halla; Raaschou, Pauline; Wettermark, Björn; Henriksson, Roger; Ye, Weimin

Survival of esophageal and gastric cancer patients with adjuvant and palliative chemotherapy-a retrospective analysis of a register-based patient cohort

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.

Bergström, Christel; Llinas, Antonio

Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per

Cell-type-resolved proteomic analysis of the human liver

Sou, Tomás; Bergström, Christel A S

Contemporary formulation development for inhaled pharmaceuticals.

Wright, Leah; Joyce, Paul; Barnes, Timothy J; Lundmark, Richard; Bergström, Christel A S; Hubert, Madlen; Prestidge, Clive A

A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics.

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.

Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver; Höök, Fredrik; Larsson, Per; Bergström, Christel A. S.

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath; Larsson, Per; Bergström, Christel; Höök, Fredrik

TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

An, Junxue; Forchheimer, Daniel; Savmarker, Jonas; Brulls, Mikael; Frenning, Göran

Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles

Teleki, Alexandra; Nylander, Olivia; Bergström, Christel

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Norinder, Ulf; Spjuth, Ola; Svensson, Fredrik

Using Predicted Bioactivity Profiles to Improve Predictive Modeling

Sinko, Patrick D.; Harris, Sarah; Salehi, Niloufar; Meyer, Pamela J.; Amidon, Gordon L.; Amidon, Gregory E.

Ultrathin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies

Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik

MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.

Dahlgren, David; Lennernäs, Hans

Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P.; Butler, J.; Holm, R.; Langguth, P.; Lindahl, A.; Muellertz, A.; Pepin, X.; Rostami-Hodjegan, A.; Sjögren, Erik; Berntsson, M.; Lennernäs, Hans

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona; Larsson, Johanna; Sandberg, Lars; Sahlberg, Sara Haggblad; Qian, Weixing; Gullberg, Hjalmar; Garg, Neeraj; Gustavsson, Anna-Lena; Haraldsson, Martin; Lane, David; Yngve, Ulrika; Lain, Sonia

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Lundsten, Sara; Hernandez, Victor Agmo; Gedda, Lars; Sarén, Tina; Brown, Christopher J.; Lane, David P.; Edwards, Katarina; Nestor, Marika

Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert

CG4928 is vital for renal function in fruit flies and membrane potential in cells: A first in-depth characterization of the putative Solute Carrier UNC93A

Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N.; Richardson, William; Lucanto, Simone; Oton, Eduard Vico; Qudus, Naim Ruhul; Mashabi, Alaa; Grossman, Scott; Ali, Sadiqur; Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Bergström, Christel; Halliday, Nigel; Mistry, Shailesh N.; Emsley, Jonas; Heeb, Stephan; Williams, Paul; Camara, Miguel; Stocks, Michael J.

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo; Bergström, Christel; Neuhoff, Sibylle; Artursson, Per; Steffansen, Bente; Nielsen, Carsten Uhd

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean; Strömme, Maria; Gogoll, A; Prestidge, Clive A; Bergström, Christel A. S.

In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier

Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena; Bergström, Christel

Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

Nakai, Daisuke; Miyake, Masateru; Hashimoto, Ayako

Comparison of the Intestinal Drug Permeation and Accumulation Between Normal Human Intestinal Tissues and Human Intestinal Tissues With Ulcerative Colitis

Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael; Sjöblom, Markus; Lennernäs, Hans

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Borro, Bruno C.; Nordström, Randi; Malmsten, Martin

Microgels and hydrogels as delivery systems for antimicrobial peptides

Wieslander, Håkan; Harrison, Philip J; Skogberg, Gabriel; Jackson, Sonya; Fridén, Marcus; Karlsson, Johan; Spjuth, Ola; Wählby, Carolina

Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

Al-Tikriti, Yassir; Hansson, Per

Drug-Eluting Polyacrylate Microgels: Loading and Release of Amitriptyline

Hedge, Oliver; Bergström, Christel A. S.

Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean; Strömme, Maria; Bergström, Christel

An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Hubert, Madlen; Larsson, Elin; Lundmark, Richard

Keeping in touch with the membrane: protein- and lipid-mediated confinement of caveolae to the cell surface

Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E.; Bergström, Christel

Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian; He, Handan; Ju, Rob; Kanodia, Jitendra; Lennernäs, Hans; Lindley, David; Polli, James E.; Wenning, Larissa; Wu, Yunhui

ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Artursson, Per; Lundquist, Patrik

A new opening for orally taken peptide drugs

Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine; Angeles, Philip Carlo; Hjelmesaeth, Jöran; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Kishani, Saina; Vilaplana, Francisco; Ruda, Marcus; Hansson, Per; Wågberg, Lars

Influence of Solubility on the Adsorption of Different Xyloglucan Fractions at Cellulose–Water Interfaces

Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per

Global variability analysis of mRNA and protein concentrations across and within human tissues

Nordström, Randi; Browning, Kathryn L.; Parra-Ortiz, Elisa; Dangaard, Liv Sofia Elinor; Malekkhaiat-Häffner, Sara; Maestro, Armando; Campbell, Richard A.; Cooper, Joshaniel F. K.; Malmsten, Martin

Membrane Interactions of Antimicrobial Peptide-Loaded Microgels

Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B; Artursson, Per

Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Ng, Adrian; O'Brien, Casey; Giannakis, Marios; Artursson, Per; Nygren, Peter; Cheong, Ian; Sjöblom, Tobias

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Pazesh, Samaneh; Persson, Ann-Sofie; Alderborn, Göran

Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern

Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian; Karlsson, Mats; Kovar, Andreas; Lehr, Thorsten; Milligan, Peter; Nock, Valerie; Ramusovic, Sergej; Riggs, Matthew; Schaller, Stephan; Schlender, Jan; Schmidt, Stephan; Sevestre, Michael; Sjögren, Erik; Solodenko, Juri; Staab, Alexander; Teutonico, Donato

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Lenhart, Vincent; Quodbach, Julian; Kleinebudde, Peter

Fibrillated Cellulose via High Pressure Homogenization: Analysis and Application for Orodispersible Films

Kulen, Martina; Nunez-Otero, Carlos; Cairns, Andrew G.; Silver, Jim; Lindgren, Anders E. G.; Wede, Emma; Singh, Pardeep; Vielfort, Katarina; Bahnan, Wael; Good, James A. D.; Svensson, Richard; Bergström, Sven; Gylfe, Åsa; Almqvist, Fredrik

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors