Institutionen för farmaci

Schmidt-Mende, Katharina; Andersen, Morten; Wettermark, Björn; Hasselstrom, Jan

Drug-disease interactions in Swedish senior primary care patients were dominated by non-steroid anti-inflammatory drugs and hypertension - a population-based registry study

Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran; Soderhall, Arvid; Hellström, Per M.; Lennernäs, Hans

Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

Ravandeh, M.; Kahlert, H.; Jablonowski, H.; Lackmann, J. -W; Striesow, J.; Agmo Hernández, Víctor; Wende, K.

A combination of electrochemistry and mass spectrometry to monitor the interaction of reactive species with supported lipid bilayers

Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Hansson, Per

Volume Transition and Phase Coexistence in Polyelectrolyte Gels Interacting with Amphiphiles and Proteins

Ekheden, Isabella; Ebrahim, Fereshte; olafsdottir, Halla; Raaschou, Pauline; Wettermark, Björn; Henriksson, Roger; Ye, Weimin

Survival of esophageal and gastric cancer patients with adjuvant and palliative chemotherapy-a retrospective analysis of a register-based patient cohort

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.

Bergström, Christel; Llinas, Antonio

Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per

Cell-type-resolved proteomic analysis of the human liver

Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath; Larsson, Per; Bergström, Christel; Höök, Fredrik

Investigating drug permeation across a lipid membrane supported on mesoporous silica.

Sou, Tomás; Bergström, Christel A S

Contemporary formulation development for inhaled pharmaceuticals.

Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver; Höök, Fredrik; Larsson, Per; Bergström, Christel A S

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers.

Wright, Leah; Joyce, Paul; Barnes, Timothy J; Lundmark, Richard; Bergström, Christel A S; Hubert, Madlen; Prestidge, Clive A

A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics.

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.

Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

An, Junxue; Forchheimer, Daniel; Savmarker, Jonas; Brulls, Mikael; Frenning, Göran

Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles

Teleki, Alexandra; Nylander, Olivia; Bergström, Christel

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Norinder, Ulf; Spjuth, Ola; Svensson, Fredrik

Using Predicted Bioactivity Profiles to Improve Predictive Modeling

Sinko, Patrick D.; Harris, Sarah; Salehi, Niloufar; Meyer, Pamela J.; Amidon, Gordon L.; Amidon, Gregory E.

Ultrathin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies

Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik

MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.

Dahlgren, David; Lennernäs, Hans

Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P.; Butler, J.; Holm, R.; Langguth, P.; Lindahl, A.; Muellertz, A.; Pepin, X.; Rostami-Hodjegan, A.; Sjögren, Erik; Berntsson, M.; Lennernäs, Hans

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona; Larsson, Johanna; Sandberg, Lars; Sahlberg, Sara Haggblad; Qian, Weixing; Gullberg, Hjalmar; Garg, Neeraj; Gustavsson, Anna-Lena; Haraldsson, Martin; Lane, David; Yngve, Ulrika; Lain, Sonia

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

Lundsten, Sara; Hernandez, Victor Agmo; Gedda, Lars; Sarén, Tina; Brown, Christopher J.; Lane, David P.; Edwards, Katarina; Nestor, Marika

Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

Van Wijk, Rob C; van der Sar, Astrid M; Krekels, Elke H J; Verboom, Theo; Spaink, Herman P; Simonsson, Ulrika S H; Van der Graaf, Piet H

Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translationa lAntituberculosis Drug Development

Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert

CG4928 is vital for renal function in fruit flies and membrane potential in cells: A first in-depth characterization of the putative Solute Carrier UNC93A

Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N.; Richardson, William; Lucanto, Simone; Oton, Eduard Vico; Qudus, Naim Ruhul; Mashabi, Alaa; Grossman, Scott; Ali, Sadiqur; Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Bergström, Christel; Halliday, Nigel; Mistry, Shailesh N.; Emsley, Jonas; Heeb, Stephan; Williams, Paul; Camara, Miguel; Stocks, Michael J.

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo; Bergström, Christel; Neuhoff, Sibylle; Artursson, Per; Steffansen, Bente; Nielsen, Carsten Uhd

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean; Strömme, Maria; Gogoll, A; Prestidge, Clive A; Bergström, Christel A. S.

In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier

Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena; Bergström, Christel

Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

Nakai, Daisuke; Miyake, Masateru; Hashimoto, Ayako

Comparison of the Intestinal Drug Permeation and Accumulation Between Normal Human Intestinal Tissues and Human Intestinal Tissues With Ulcerative Colitis

Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael; Sjöblom, Markus; Lennernäs, Hans

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Borro, Bruno C.; Nordström, Randi; Malmsten, Martin

Microgels and hydrogels as delivery systems for antimicrobial peptides

Al-Tikriti, Yassir; Hansson, Per

Drug-Eluting Polyacrylate Microgels: Loading and Release of Amitriptyline

Hedge, Oliver; Bergström, Christel A. S.

Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean; Strömme, Maria; Bergström, Christel

An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Hubert, Madlen; Larsson, Elin; Lundmark, Richard

Keeping in touch with the membrane: protein- and lipid-mediated confinement of caveolae to the cell surface

Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E.; Bergström, Christel

Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian; He, Handan; Ju, Rob; Kanodia, Jitendra; Lennernäs, Hans; Lindley, David; Polli, James E.; Wenning, Larissa; Wu, Yunhui

ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Artursson, Per; Lundquist, Patrik

A new opening for orally taken peptide drugs

Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine; Angeles, Philip Carlo; Hjelmesaeth, Jöran; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Kishani, Saina; Vilaplana, Francisco; Ruda, Marcus; Hansson, Per; Wågberg, Lars

Influence of Solubility on the Adsorption of Different Xyloglucan Fractions at Cellulose–Water Interfaces

Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per

Global variability analysis of mRNA and protein concentrations across and within human tissues

Nordström, Randi; Browning, Kathryn L.; Parra-Ortiz, Elisa; Dangaard, Liv Sofia Elinor; Malekkhaiat-Häffner, Sara; Maestro, Armando; Campbell, Richard A.; Cooper, Joshaniel F. K.; Malmsten, Martin

Membrane Interactions of Antimicrobial Peptide-Loaded Microgels

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Ng, Adrian; O'Brien, Casey; Giannakis, Marios; Artursson, Per; Nygren, Peter; Cheong, Ian; Sjöblom, Tobias

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Pazesh, Samaneh; Persson, Ann-Sofie; Alderborn, Göran

Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern

Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian; Karlsson, Mats; Kovar, Andreas; Lehr, Thorsten; Milligan, Peter; Nock, Valerie; Ramusovic, Sergej; Riggs, Matthew; Schaller, Stephan; Schlender, Jan; Schmidt, Stephan; Sevestre, Michael; Sjögren, Erik; Solodenko, Juri; Staab, Alexander; Teutonico, Donato

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Lenhart, Vincent; Quodbach, Julian; Kleinebudde, Peter

Fibrillated Cellulose via High Pressure Homogenization: Analysis and Application for Orodispersible Films

Kulen, Martina; Nunez-Otero, Carlos; Cairns, Andrew G.; Silver, Jim; Lindgren, Anders E. G.; Wede, Emma; Singh, Pardeep; Vielfort, Katarina; Bahnan, Wael; Good, James A. D.; Svensson, Richard; Bergström, Sven; Gylfe, Åsa; Almqvist, Fredrik

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

Malekkhaiat Häffner, Sara; Nyström, Lina; Strömstedt, Adam A.; Li, Li; van der Plas, Mariena J A; Malmsten, Martin

Nanoclay-induced bacterial flocculation for infection confinement

Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär; Artursson, Per

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

Sjögren, Erik; Stahle, Lars; Quiding, Hans; Jonzon, Bror; Halldin, Magnus M.; Sundgren, Anna K.

The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers

Ilyas, Humaira; Kim, JaeWoong; Lee, DongKuk; Malmsten, Martin; Bhunia, Anirban

Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism

Norling, Karin; Bernasconi, Valentina; Agmo Hernandez, Victor; Parveen, Nagma; Edwards, Katarina; Lycke, Nils Y; Höök, Fredrik; Bally, Marta

Gel Phase 1,2-Distearoyl-sn-glycero-3-phosphocholine-Based Liposomes Are Superior to Fluid Phase Liposomes at Augmenting Both Antigen Presentation on Major Histocompatibility Complex Class II and Costimulatory Molecule Display by Dendritic Cells in Vitro

Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A.; Tannergren, C.; Sjögren, Erik; Sjöblom, Markus; Lennernäs, Hans

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik; Lennernäs, Hans

Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Reis, Pedro; Malmsten, Martin; Nydén, Magnus; Folmer, Britta; Holmberg, Krister

Interactions between Lipases and Amphiphiles at Interfaces

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik; Hansson, Per; Lennernäs, Hans

Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Dahlgren, David; Lennernäs, Hans

Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A.; Lai, Yurong; Smith, Philip C.; Barber, Jill; Wisniewski, Jacek R.; Spellman, Daniel; Uchida, Yasuo; Zientek, Michael A.; Unadkat, Jashvant D.; Rostami-Hodjegan, Amin

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier; Karlgren, Maria; Bergström, Christel; Nielsen, Carsten Uhd; Steffansen, Bente

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin; Brouwers, Joachim; Augustijns, Patrick; Brandl, Martin; Bernkop-Schnürch, Andreas; Shrestha, Neha; Preat, Veronique; Müllertz, Anette; Bauer-Brandl, Annette; Jannin, Vincent

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?