Institutionen för farmaci

Cresswell, Fiona, V; Meya, David B.; Kagimu, Enock; Grint, Daniel; Te Brake, Lindsey; Kasibante, John; Martyn, Emily; Rutakingirwa, Morris; Quinn, Carson M.; Okirwoth, Micheal; Tugume, Lillian; Ssembambulidde, Kenneth; Musubire, Abdu K.; Bangdiwala, Ananta S.; Buzibye, Allan; Muzoora, Conrad; Svensson, Elin; Aarnoutse, Rob; Boulware, David R.; Elliott, Alison M.

High-Dose Oral and Intravenous Rifampicin for the Treatment of Tuberculous Meningitis in Predominantly Human Immunodeficiency Virus (HIV)-Positive Ugandan Adults: A Phase II Open-Label Randomized Controlled Trial

Luptáková, Dominika; Vallianatou, Theodosia; Nilsson, Anna; Shariatgorji, Reza; Hammarlund-Udenaes, Margareta; Loryan, Irena; Andrén, Per E

Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood-brain barrier.

Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna; Shariatgorji, Reza; Haldimann, Klara; Platzack, Bjorn; Hughes, Diarmaid; Andrén, Per E.; Bottger, Erik C.; Friberg, Lena E.; Hobbie, Sven N.

Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice

van Doorn, Leni; van Rosmalen, Mandy M.; van der Deure, Wendy M.; Oomen-de Hoop, Esther; Porrazzo, Robert; Wijngaard, Sophie M.; Boere, Ingrid A.; Veenstra, Paola; Ibrahim, Eman; de Bruijn, Peter; Friberg, Lena; Koolen, Stijn L. W.; Mathijssen, Ron H. J.; Jager, Agnes

Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel

Nyberg, Fredrik; Franzen, Stefan; Lindh, Magnus; Vanfleteren, Lowie; Hammar, Niklas; Wettermark, Björn; Sundström, Johan; Santosa, Ailiana; Bjorck, Staffan; Gisslen, Magnus

Swedish Covid-19 Investigation for Future Insights-A Population Epidemiology Approach Using Register Linkage (SCIFI-PEARL)

Loikas, Desiree; Linner, Love; Sundström, Anders; Wettermark, Björn; von Euler, Mia

Post-stroke epilepsy and antiepileptic drug use in men and women

Wicha, Sebastian G.; Martson, Anne-Grete; Nielsen, Elisabet I.; Koch, Birgit C. P.; Friberg, Lena; Alffenaar, Jan-Willem; Minichmayr, Iris

From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

van Beek, Stijn W.; ter Heine, Rob; Alffenaar, Jan-Willem C.; Magis-Escurra, Cecile; Aarnoutse, Rob E.; Svensson, Elin M.

A Model-Informed Method for the Purpose of Precision Dosing of Isoniazid in Pulmonary Tuberculosis

Sturkenboom, Marieke G. G.; Martson, Anne-Grete; Svensson, Elin; Sloan, Derek J.; Dooley, Kelly E.; van den Elsen, Simone H. J.; Denti, Paolo; Peloquin, Charles A.; Aarnoutse, Rob E.; Alffenaar, Jan-Willem C.

Population Pharmacokinetics and Bayesian Dose Adjustment to Advance TDM of Anti-TB Drugs

Druedahl, Louise C.; Kälvemark Sporrong, Sofia; van de Weert, Marco; De Bruin, Marie Louise; Hoogland, Hans; Minssen, Timo; Almarsdottir, Anna Birna

Evolving Biosimilar Clinical Requirements: A Qualitative Interview Study with Industry Experts and European National Medicines Agency Regulators

Van Daele, Ruth; Debaveye, Yves; Vos, Robin; Van Bleyenbergh, Pascal; Bruggemann, Roger J.; Dreesen, Erwin; Elkayal, Omar; Guchelaar, Henk-Jan; Vermeersch, Pieter; Lagrou, Katrien; Spriet, Isabel

Concomitant use of isavuconazole and CYP3A4/5 inducers: Where pharmacogenetics meets pharmacokinetics

Krishnan, Sreenath Madathil; Laarif, Sofiene S.; Bender, Brendan C.; Quartino, Angelica L.; Friberg, Lena

Tumor growth inhibition modeling of individual lesion dynamics and interorgan variability in HER2-negative breast cancer patients treated with docetaxel

Teleki, Alexandra; Artursson, Per

Getting a grip with kirigami

Rowland Yeo, Karen; Hennig, Stefanie; Krishnaswami, Sriram; Strydom, Natasha; Ayyar, Vivaswath S.; French, Jonathan; Sinha, Vikram; Sobie, Eric; Zhao, Ping; Friberg, Lena E.; Mentre, France

CPT: Pharmacometrics & Systems Pharmacology - Inception, Maturation, and Future Vision

Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Neumann, Nicole G.; Morrison, Jamie; Syvänen, Stina; Andrén, Per E.; Jansson, Erik T.; Hultqvist, Greta

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Efthymiou, Christina; Bergström, Magnus; Pedersen, Jannik Nedergaard; Pedersen, Jan Skov; Hansson, Per

Self-assembling properties of ionisable amphiphilic drugs in aqueous solution

Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P.; Rendo, Verónica; Artursson, Per; He, Liqun; Globisch, Daniel; Sjöblom, Tobias

Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis

Keemink, Janneke; Hedge, Oliver; Bianco, Valentina; Hubert, Madlen; Bergström, Christel

Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay

Hedge, Oliver; Höök, Fredrik; Joyce, Paul; Bergström, Christel

Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine

Hempel, Nele-Johanna; Merkl, Padryk; Knopp, Matthias Manne; Berthelsen, Ragna; Teleki, Alexandra; Hansen, Anders Kragh; Sotiriou, Georgios A.; Löbmann, Korbinian

The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In Situ Amorphization

Hempel, Nele-Johanna; Merkl, Padryk; Asad, Shno; Knopp, Matthias Manne; Berthelsen, Ragna; Bergström, Christel; Teleki, Alexandra; Sotiriou, Georgios A.; Löbmann, Korbinian

Utilizing Laser Activation of Photothermal Plasmonic Nanoparticles to Induce On-Demand Drug Amorphization inside a Tablet

Bukkems, Vera E.; Post, Teun M.; Colbers, Angela P.; Burger, David M.; Svensson, Elin

A population pharmacokinetics analysis assessing the exposure of raltegravir once-daily 1200 mg in pregnant women living with HIV

Hempel, Nele-Johanna; Merkl, Padryk; Knopp, Matthias Manne; Berthelsen, Ragna; Teleki, Alexandra; Sotiriou, Georgios A.; Löbmann, Korbinian

The Influence of Drug-Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

Llanos-Paez, Carolina; Ambery, Claire; Yang, Shuying; Tabberer, Maggie; Beerahee, Misba; Plan, Elodie L.; Karlsson, Mats O.

Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial

Ágh, Tamás; van Boven, Job F. M.; Wettermark, Björn; Menditto, Enrica; Pinnock, Hilary; Tsiligianni, Ioanna; Petrova, Guenka; Potocnjak, Ines; Kamberi, Fatjona; Kardas, Przemyslaw

A Cross-Sectional Survey on Medication Management Practices for Noncommunicable Diseases in Europe During the Second Wave of the COVID-19 Pandemic

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin; Gising, Johan; Baranczewski, Pawel; Vingsbo Lundberg, Carina; Karlén, Anders

ENABLE: an engine for European antibacterial drug discovery and development

Vallianatou, Theodosia; Shariatgorji, Reza; Nilsson, Anna; Karlgren, Maria; Hulme, Heather; Fridjonsdottir, Elva; Svenningsson, Per; Andrén, Per E.

Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain

Kardas, Przemyslaw; van Boven, Job Frank Martien; Pinnock, Hilary; Menditto, Enrica; Wettermark, Björn; Tsiligianni, Ioanna; Aghh, Tamas

Disparities in European healthcare system approaches to maintaining continuity of medication for non-communicable diseases during the COVID-19 outbreak Comment

Karlsson, Oskar; Svanholm, Sofie; Eriksson, Andreas; Chidiac, Joseph; Eriksson, Johanna; Jernerén, Fredrik; Berg, Cecilia

Pesticide-induced multigenerational effects on amphibian reproduction and metabolism

Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah; Berben, Philippe; Bernkop-Schnürch, Andreas; Butler, James; Ceulemans, Jens; Davies, Nigel; Dupont, Didier; Flaten, Gøril Eide; Fotaki, Nikoletta; Griffin, Brendan T.; Jannin, Vincent; Keemink, Janneke; Kesisoglou, Filippos; Koziolek, Mirko; Kuentz, Martin; Mackie, Alan; Meléndez-Martínez, Antonio J.; McAllister, Mark; Müllertz, Anette; O'Driscoll, Caitriona M.; Parrott, Neil; Paszkowska, Jadwiga; Pavek, Petr; Porter, Christopher J. H.; Reppas, Christos; Stillhart, Cordula; Sugano, Kiyohiko; Toader, Elena; Valentová, Katerina; Vertzoni, Maria; De Wildt, Saskia N.; Wilson, Clive G.; Augustijns, Patrick

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Chen, Chao; Jönsson, Siv; Yang, Shuying; Plan, Elodie L.; Karlsson, Mats

Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item-score models

Minichmayr, Iris K.; Karlsson, Mats O.; Jönsson, Siv

Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety

Gijsen, Matthias; Dreesen, Erwin; Van Daele, Ruth; Annaert, Pieter; Debaveye, Yves; Wauters, Joost; Spriet, Isabel

Pharmacokinetic/Pharmacodynamic Target Attainment Based on Measured versus Predicted Unbound Ceftriaxone Concentrations in Critically Ill Patients with Pneumonia: An Observational Cohort Study

Chasseloup, Estelle; Tessier, Adrien; Karlsson, Mats

Assessing Treatment Effects with Pharmacometric Models: A New Method that Addresses Problems with Standard Assessments

Dahlgren, David; Sjöblom, Markus; Hellström, Per M.; Lennernäs, Hans

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Friberg, Lena E.

Pivotal Role of Translation in Anti-Infective Development

Rayner, Craig R.; Smith, Patrick F.; Andes, David; Andrews, Kayla; Derendorf, Hartmut; Friberg, Lena E.; Hanna, Debra; Lepak, Alex; Mills, Edward; Polasek, Thomas M.; Roberts, Jason A.; Schuck, Virna; Shelton, Mark J.; Wesche, David; Rowland-Yeo, Karen

Model-Informed Drug Development for Anti-Infectives: State of the Art and Future

Wellhagen, Gustaf; Ueckert, Sebastian; Kjellsson, Maria C.; Karlsson, Mats

An Item Response Theory-Informed Strategy to Model Total Score Data from Composite Scales

Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer; Lisspers, Karin; Malinovschi, Andrei; Melhus, Håkan; Ställberg, Björn; Nielsen, Elisabet I.

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Salo-Ahen, Outi M. H.; Alanko, Ida; Bhadane, Rajendra; Bonvin, Alexandre M. J. J.; Honorato, Rodrigo Vargas; Hossain, Md Shakhawath; Juffer, Andre H.; Kabedev, Aleksei; Lahtela-Kakkonen, Maija; Larsen, Anders Stottrup; Lescrinier, Eveline; Marimuthu, Parthiban; Mirza, Muhammad Usman; Mustafa, Ghulam; Nunes-Alves, Ariane; Pantsar, Tatu; Saadabadi, Atefeh; Singaravelu, Kalaimathy; Vanmeert, Michiel

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

Johannesson, Jenny; Khan, Jamal; Hubert, Madlen; Teleki, Alexandra; Bergström, Christel

3D-printing of solid lipid tablets from emulsion gels

Alzayer, Reem; Svedin, Elin; Rizvi, Soha Aftab; Basheti, Iman; Chaar, Betty; Saini, Bandana

Pharmacists' experience of asthma management in culturally and linguistically diverse (CALD) patients

Hossain, Md Shakhawath; Kabedev, Aleksei

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica; Gutiérrez-de-Terán, Hugo; Ablahad, Hanin; Hamid, Selin; Grönbladh, Alfhild; Spizzo, Iresha; Gaspari, Tracey A.; Widdop, Robert E.; Hallberg, Anders; Backlund, Maria; Leśniak, Anna; Hallberg, Mathias; Larhed, Mats

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S.; Phillipson, Mia; Artursson, Per; Teleki, Alexandra

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Berg, Staffan; Krause, Julius; Björkbom, Anders; Walter, Katrin; Harun, Said; Granfeldt, Andreas; Janzén, David; Nunes, Sandro Filipe; Antonsson, Malin; Van Zuydam, Natalie; Skrtic, Stanko; Hugerth, Andreas; Weitschies, Werner; Davies, Nigel; Abrahamsson, Bertil; Bergström, Christel

In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Kuentz, Martin; Bergström, Christel A.S.

Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

Kempen, Thomas; Bertilsson, Maria; Hadziosmanovic, Nermin; Lindner, Karl-Johan; Melhus, Håkan; Nielsen, Elisabet I.; Sulku, Johanna; Gillespie, Ulrika

Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Matsson, Pär; Baranczewski, Pawel; Giacomini, Kathleen M.; Andersson, Tommy B.; Palm, Johan; Palm, Katrin; Charman, William N.; Bergström, Christel A.S.

A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

Kabedev, Aleksei; Hossain, Shakhawath; Hubert, Madlen; Larsson, Per; Bergström, Christel A. S.

Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

Ueckert, Sebastian; Karlsson, Mats

Improved numerical stability for the bounded integer model

Davies Forsman, Lina; Niward, Katarina; Kuhlin, Johanna; Zheng, Xubin; Zheng, Rongrong; Ke, Ran; Hong, Chao; Werngren, Jim; Paues, Jakob; Simonsson, Ulrika S. H.; Eliasson, Erik; Hoffner, Sven; Xu, Biao; Alffenaar, Jan-Willem; Schön, Thomas; Hu, Yi; Bruchfeld, Judith

Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria; Ercan, Onur; Grinberga, Solveiga; Cao, Sha; Giachou, Paraskevi; Petersson, Anna; Tomczak, Magdalena; Urbas, Malgorzata; Zabicka, Dorota; Vingsbo Lundberg, Carina; Hughes, Diarmaid; Hobbie, Sven N; Friberg, Lena

Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin

Ibrahim, Moustafa M. A.; Redestad, Erik; Kjellsson, Maria C.

Optimal Designs for Model-Based Assessment of Insulin Sensitivity and Glucose Effectiveness.

Wellhagen, Gustaf J.; Karlsson, Mats O.; Kjellsson, Maria C.

Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data

Leohr, Jennifer; Heathman, Michael; Kjellsson, Maria C.

Postprandial triglyceride reduction following acute treatment of a selective 5-hydroxytryptamine-2c agonist and characterization using a semi-physiological model

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wright, Leah; Joyce, Paul; Barnes, Timothy J.; Lundmark, Richard; Bergström, Christel A. S.; Hubert, Madlen; Prestidge, Clive A.

A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics

Sou, Tomás; Bergström, Christel A. S.

Contemporary formulation development for inhaled pharmaceuticals

Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath; Larsson, Per; Bergström, Christel; Höök, Fredrik

TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

Wieslander, Håkan; Harrison, Philip J.; Skogberg, Gabriel; Jackson, Sonya; Fridén, Markus; Karlsson, Johan; Spjuth, Ola; Wählby, Carolina

Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef; Christensen, Hege; Andersson, Tommy B.; Artursson, Per

Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B; Artursson, Per

Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

Ölander, Magnus; Wegler, Christine; Flörkemeier, Inken; Treyer, Andrea; Handin, Niklas; Pedersen, Jenny M.; Vildhede, Anna; Mateus, André; LeCluyse, Edward L.; Urdzik, Jozef; Artursson, Per

Hepatocyte size fractionation allows dissection of human liver zonation

Salas, Maribel; Lopes, Luciane C.; Godman, Brian; Truter, Ilse; Hartzema, Abraham G.; Wettermark, Björn; Fadare, Joseph; Burger, Johanita R.; Appenteng, Kwame; Donneyong, Macarius; Arias, Ariel; Ankrah, Daniel; Ogunleye, Olayinka O.; Lubbe, Martha; Horne, Laura; Bernet, Jorgelina; Gomez-Galicia, Diana L.; Garcia Estrada, Miriam del Carmen; Oluka, Margaret N.; Massele, Amos; Alesso, Luis; Comoglio, Raquel Herrera; Lima, Elisangela Costa; Vilaseca, Carmen; Bergman, Ulf

Challenges facing drug utilization research in the Latin American region

Chasseloup, Estelle; Yngman, Gunnar; Karlsson, Mats

Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both?

Jowkar, Nima; Fjeldso, Nina; Norgaard, Lotte Stig; Kälvemark Sporrong, Sofia; Jacobsen, Ramune; Kaae, Susanne

A Presentation of Central Communication Aspects in the Patient-Provider Relationship-Potential Learnings for Community Pharmacists

Wang, Zhigang; Dreesen, Erwin

Therapeutic drug monitoring of anti-tumor necrosis factor agents: lessons learned and remaining issues

Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E; Hooker, Andrew; Rostami-Hodjegan, Amin; Schmidt, Stephan; Suarez-Sharp, Sandra; Lukacova, Viera; Fang, Lanyan; Zhao, Liang

Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z.; Houston, J. Brian; Kansy, Manfred; Kerns, Edward H.; Lennernäs, Hans; Smith, Dennis A.; Sugano, Kiyohiko

The Critical Role of Passive Permeability in Designing Successful Drugs