Institutionen för farmaci

Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N.; Richardson, William; Lucanto, Simone; Oton, Eduard Vico; Qudus, Naim Ruhul; Mashabi, Alaa; Grossman, Scott; Ali, Sadiqur; Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Bergström, Christel; Halliday, Nigel; Mistry, Shailesh N.; Emsley, Jonas; Heeb, Stephan; Williams, Paul; Camara, Miguel; Stocks, Michael J.

Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo; Bergström, Christel; Neuhoff, Sibylle; Artursson, Per; Steffansen, Bente; Nielsen, Carsten Uhd

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean; Strömme, Maria; Gogoll, Adolf; Prestidge, Clive A; Bergström, Christel A S

In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier.

Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena

Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption

Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena; Bergström, Christel

Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

Larsson, Per; Kneiszl, Rosita; Marklund, Erik

MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all‐atom molecular dynamics simulations

Nakai, Daisuke; Miyake, Masateru; Hashimoto, Ayako

Comparison of the Intestinal Drug Permeation and Accumulation Between Normal Human Intestinal Tissues and Human Intestinal Tissues With Ulcerative Colitis

Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael; Sjöblom, Markus; Lennernäs, Hans

Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat

Borro, Bruno C.; Nordström, Randi; Malmsten, Martin

Microgels and hydrogels as delivery systems for antimicrobial peptides

Al-Tikriti, Yassir; Hansson, Per

Drug-Eluting Polyacrylate Microgels: Loading and Release of Amitriptyline

Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean; Strömme, Maria; Bergström, Christel

An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

Hedge, Oliver; Bergström, Christel A. S.

Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin

Hubert, Madlen; Larsson, Elin; Lundmark, Richard

Keeping in touch with the membrane: protein- and lipid-mediated confinement of caveolae to the cell surface

Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E.; Bergström, Christel

Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian; He, Handan; Ju, Rob; Kanodia, Jitendra; Lennernäs, Hans; Lindley, David; Polli, James E.; Wenning, Larissa; Wu, Yunhui

ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium

Artursson, Per; Lundquist, Patrik

A new opening for orally taken peptide drugs.

Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine; Angeles, Philip Carlo; Hjelmesaeth, Jöran; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege

A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

Kishani, Saina; Vilaplana, Francisco; Ruda, Marcus; Hansson, Per; Wågberg, Lars

Influence of Solubility on the Adsorption of Different Xyloglucan Fractions at Cellulose–Water Interfaces

Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per

Global variability analysis of mRNA and protein concentrations across and within human tissues

Nordström, Randi; Browning, Kathryn L.; Parra-Ortiz, Elisa; Dangaard, Liv Sofia Elinor; Malekkhaiat-Häffner, Sara; Maestro, Armando; Campbell, Richard A.; Cooper, Joshaniel F. K.; Malmsten, Martin

Membrane Interactions of Antimicrobial Peptide-Loaded Microgels

Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Ng, Adrian; O'Brien, Casey; Giannakis, Marios; Artursson, Per; Nygren, Peter; Cheong, Ian; Sjöblom, Tobias

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian; Karlsson, Mats; Kovar, Andreas; Lehr, Thorsten; Milligan, Peter; Nock, Valerie; Ramusovic, Sergej; Riggs, Matthew; Schaller, Stephan; Schlender, Jan; Schmidt, Stephan; Sevestre, Michael; Sjögren, Erik; Solodenko, Juri; Staab, Alexander; Teutonico, Donato

Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences

Lenhart, Vincent; Quodbach, Julian; Kleinebudde, Peter

Fibrillated Cellulose via High Pressure Homogenization: Analysis and Application for Orodispersible Films

Kulen, Martina; Nunez-Otero, Carlos; Cairns, Andrew G.; Silver, Jim; Lindgren, Anders E. G.; Wede, Emma; Singh, Pardeep; Vielfort, Katarina; Bahnan, Wael; Good, James A. D.; Svensson, Richard; Bergström, Sven; Gylfe, Åsa; Almqvist, Fredrik

Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors

Malekkhaiat Häffner, Sara; Nyström, Lina; Strömstedt, Adam A.; Li, Li; van der Plas, Mariena J A; Malmsten, Martin

Nanoclay-induced bacterial flocculation for infection confinement

Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär; Artursson, Per

A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

Sjögren, Erik; Stahle, Lars; Quiding, Hans; Jonzon, Bror; Halldin, Magnus M.; Sundgren, Anna K.

The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers

Ilyas, Humaira; Kim, JaeWoong; Lee, DongKuk; Malmsten, Martin; Bhunia, Anirban

Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism

Norling, Karin; Bernasconi, Valentina; Agmo Hernandez, Victor; Parveen, Nagma; Edwards, Katarina; Lycke, Nils Y; Höök, Fredrik; Bally, Marta

Gel Phase 1,2-Distearoyl-sn-glycero-3-phosphocholine-Based Liposomes Are Superior to Fluid Phase Liposomes at Augmenting Both Antigen Presentation on Major Histocompatibility Complex Class II and Costimulatory Molecule Display by Dendritic Cells in Vitro

Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A.; Tannergren, C.; Sjögren, Erik; Sjöblom, Markus; Lennernäs, Hans

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik; Lennernäs, Hans

Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Reis, Pedro; Malmsten, Martin; Nydén, Magnus; Folmer, Britta; Holmberg, Krister

Interactions between Lipases and Amphiphiles at Interfaces

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik; Hansson, Per; Lennernäs, Hans

Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Dahlgren, David; Lennernäs, Hans

Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A.; Lai, Yurong; Smith, Philip C.; Barber, Jill; Wisniewski, Jacek R.; Spellman, Daniel; Uchida, Yasuo; Zientek, Michael A.; Unadkat, Jashvant D.; Rostami-Hodjegan, Amin

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier; Karlgren, Maria; Bergström, Christel; Nielsen, Carsten Uhd; Steffansen, Bente

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin; Brouwers, Joachim; Augustijns, Patrick; Brandl, Martin; Bernkop-Schnürch, Andreas; Shrestha, Neha; Preat, Veronique; Müllertz, Anette; Bauer-Brandl, Annette; Jannin, Vincent

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa; Rubin, Katarina; Lennernäs, Hans

Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

Boge, Lukas; Browning, Kathryn L.; Nordström, Randi; Campana, Mario; Darngaard, Liv S. E.; Caous, Josefin Seth; Hellsing, Maja; Ringstad, Lovisa; Andersson, Martin

Peptide-Loaded Cubosomes Functioning as an Antimicrobial Unit against Escherichia coil

Charalabidis, Aggelos; Sfouni, Maria; Bergström, Christel; Macheras, Panos

The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit; Fowler, Stephen; Artursson, Per

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Edueng, Khadijah; Bergström, Christel; Gråsjö, Johan; Mahlin, Denny

Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

Edueng, Khadijah; Mahlin, Denny; Gråsjö, Johan; Nylander, Olivia; Thakrani, Manish; Bergström, Christel

Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

Zhang, Yuning; Andren, Oliver C. J.; Nordström, Randi; Fan, Yanmiao; Malmsten, Martin; Mongkhontreerat, Surinthra; Malkoch, Michael

Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics

Nordström, Randi; Andrén, Oliver C.J.; Singh, Shalini; Malkoch, Michael; Davoudi, Mina; Schmidtchen, Artur; Malmsten, Martin

Degradable dendritic nanogels as carriers for antimicrobial peptides

Bergström, Christel; Box, Karl; Holm, Rene; Matthews, Wayne; McAllister, Mark; Mullertz, Anette; Rades, Thomas; Schäfer, Kerstin J.; Teleki, Alexandra

Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

Thunander Sundbom, Lena; Hedborg, Kerstin

Association between prescribed antidepressants and other prescribed drugs differ by gender: a nationwide register-based study in Sweden

Bergström, Christel A.S.; Avdeef, Alex

Perspectives in solubility measurement and interpretation

Häffner, Sara Malekkhaiat; Nyström, Lina; Browning, Kathryn L.; Nielsen, Hanne Mörck; Strömstedt, Adam A.; van der Plas, Mariena J. A.; Schmidtchen, Artur; Malmsten, Martin

Interaction of Laponite with Membrane Components - Consequences for Bacterial Aggregation and Infection Confinement

Mohid, Sk Abdul; Ghorai, Arup; Ilyas, Humaira; Mroue, Kamal H.; Narayanan, Gomathy; Sarkar, Abhisek; Ray, Samit K.; Biswas, Kaushik; Bera, Amal Kanti; Malmsten, Martin; Midya, Anupam; Bhunia, Anirban

Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre; An, Junxue; Alderborn, Göran

Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model

El-Serafi, Ahmed T.; Sandeep, Divyasree; Abdallah, Sallam; Lozansson, Yasmin; Hamad, Moawiah; Khan, Amir A.

Paradoxical effects of the epigenetic modifiers 5-aza-deoxycytidine and suberoylanilide hydroxamic acid on adipogenesis

Hossain, Md Shakhawath; Kabedev, Aleksei; Parrow, Albin; Bergström, Christel; Larsson, Per

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

Karlsson, Rose-Marie Pernilla; Larsson, Per Tomas; Hansson, Per; Wågberg, Lars

Thermodynamics of the Water-Retaining Properties of Cellulose-Based Networks

Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel; Artursson, Per

Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Ölander, Magnus; Handin, Niklas; Artursson, Per

Image-based quantification of cell debris as a measure of apoptosis

Kishani, Saina; Escalante, Alfredo; Toriz, Guillermo; Vilaplana, Francisco; Gatenholm, Paul; Hansson, Per; Wagberg, Lars

Experimental and Theoretical Evaluation of the Solubility/Insolubility of Spruce Xylan (Arabino Glucuronoxylan)

Brekkan, Ari; Lopez-Lazaro, Luis; Plan, Elodie L.; Nyberg, Joakim; Kankanwadi, Suresh; Karlsson, Mats

Pharmacokinetic and Pharmacodynamic Sensitivity of Pegfilgrastim

Yang, Jing; An, Junxue; Tong, Lianpeng; Long, Baihua; Fan, Ting; Duan, Lele

Sulfur Coordination Effects on the Stability and Activity of a Ruthenium-Based Water Oxidation Catalyst

Keemink, Janneke; Martensson, Elin; Bergström, Christel

Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Wisell, Kristin; Winblad, Ulrika; Kälvemark Sporrong, Sofia

Diversity as salvation?: A comparison of the diversity rationale in the Swedish pharmacy ownership liberalization reform and the primary care choice reform

Artursson, Per

Experimental approaches to understand intracellular based drug bioavailability

Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa; Ericsson, Hans; Lennernäs, Hans; Lundahl, Anna

Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

Parra-Ortiz, Elisa; Browning, Kathryn L.; Damgaard, Liv S. E.; Nordström, Randi; Micciulla, Samantha; Bucciarelli, Saskia; Malmsten, Martin

Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes

Heimbach, Tycho; Suarez-Sharp, Sandra; Kakhi, Maziar; Holmstock, Nico; Olivares-Morales, Andres; Pepin, Xavier; Sjögren, Erik; Tsakalozou, Eleftheria; Seo, Paul; Li, Min; Zhang, Xinyuan; Lin, Ho-Pi; Montague, Timothy; Mitra, Amitava; Morris, Denise; Patel, Nikunjkumar; Kesisoglou, Filippos

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report