Institutionen för farmaci

Hempel, Nele-Johanna; Merkl, Padryk; Knopp, Matthias Manne; Berthelsen, Ragna; Teleki, Alexandra; Sotiriou, Georgios A.; Löbmann, Korbinian

The Influence of Drug-Polymer Solubility on Laser-Induced In Situ Drug Amorphization Using Photothermal Plasmonic Nanoparticles

Llanos-Paez, Carolina; Ambery, Claire; Yang, Shuying; Tabberer, Maggie; Beerahee, Misba; Plan, Elodie L.; Karlsson, Mats O.

Improved Decision-Making Confidence Using Item-Based Pharmacometric Model: Illustration with a Phase II Placebo-Controlled Trial

Ágh, Tamás; van Boven, Job F. M.; Wettermark, Björn; Menditto, Enrica; Pinnock, Hilary; Tsiligianni, Ioanna; Petrova, Guenka; Potocnjak, Ines; Kamberi, Fatjona; Kardas, Przemyslaw

A Cross-Sectional Survey on Medication Management Practices for Noncommunicable Diseases in Europe During the Second Wave of the COVID-19 Pandemic

Olliver, Marie; Griestop, Laura; Hughes, Diarmaid; Belfrage, Anna Karin; Gising, Johan; Baranczewski, Pawel; Vingsbo Lundberg, Carina; Karlén, Anders

ENABLE: an engine for European antibacterial drug discovery and development

Kardas, Przemyslaw; van Boven, Job Frank Martien; Pinnock, Hilary; Menditto, Enrica; Wettermark, Björn; Tsiligianni, Ioanna; Aghh, Tamas

Disparities in European healthcare system approaches to maintaining continuity of medication for non-communicable diseases during the COVID-19 outbreak Comment

Vallianatou, Theodosia; Shariatgorji, Reza; Nilsson, Anna; Karlgren, Maria; Hulme, Heather; Fridjonsdottir, Elva; Svenningsson, Per; Andrén, Per E.

Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain

Karlsson, Oskar; Svanholm, Sofie; Eriksson, Andreas; Chidiac, Joseph; Eriksson, Johanna; Jernerén, Fredrik; Berg, Cecilia

Pesticide-induced multigenerational effects on amphibian reproduction and metabolism

Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah; Berben, Philippe; Bernkop-Schnürch, Andreas; Butler, James; Ceulemans, Jens; Davies, Nigel; Dupont, Didier; Flaten, Gøril Eide; Fotaki, Nikoletta; Griffin, Brendan T.; Jannin, Vincent; Keemink, Janneke; Kesisoglou, Filippos; Koziolek, Mirko; Kuentz, Martin; Mackie, Alan; Meléndez-Martínez, Antonio J.; McAllister, Mark; Müllertz, Anette; O'Driscoll, Caitriona M.; Parrott, Neil; Paszkowska, Jadwiga; Pavek, Petr; Porter, Christopher J. H.; Reppas, Christos; Stillhart, Cordula; Sugano, Kiyohiko; Toader, Elena; Valentová, Katerina; Vertzoni, Maria; De Wildt, Saskia N.; Wilson, Clive G.; Augustijns, Patrick

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Chen, Chao; Jönsson, Siv; Yang, Shuying; Plan, Elodie L.; Karlsson, Mats

Detecting placebo and drug effects on Parkinson's disease symptoms by longitudinal item-score models

Minichmayr, Iris K.; Karlsson, Mats O.; Jönsson, Siv

Pharmacometrics-Based Considerations for the Design of a Pharmacogenomic Clinical Trial Assessing Irinotecan Safety

Gijsen, Matthias; Dreesen, Erwin; Van Daele, Ruth; Annaert, Pieter; Debaveye, Yves; Wauters, Joost; Spriet, Isabel

Pharmacokinetic/Pharmacodynamic Target Attainment Based on Measured versus Predicted Unbound Ceftriaxone Concentrations in Critically Ill Patients with Pneumonia: An Observational Cohort Study

Chasseloup, Estelle; Tessier, Adrien; Karlsson, Mats

Assessing Treatment Effects with Pharmacometric Models: A New Method that Addresses Problems with Standard Assessments

Dahlgren, David; Sjöblom, Markus; Hellström, Per M.; Lennernäs, Hans

Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies

Friberg, Lena

Pivotal Role of Translation in Anti-Infective Development

Rayner, Craig R.; Smith, Patrick F.; Andes, David; Andrews, Kayla; Derendorf, Hartmut; Friberg, Lena E.; Hanna, Debra; Lepak, Alex; Mills, Edward; Polasek, Thomas M.; Roberts, Jason A.; Schuck, Virna; Shelton, Mark J.; Wesche, David; Rowland-Yeo, Karen

Model-Informed Drug Development for Anti-Infectives: State of the Art and Future

Wellhagen, Gustaf; Ueckert, Sebastian; Kjellsson, Maria C.; Karlsson, Mats

An Item Response Theory-Informed Strategy to Model Total Score Data from Composite Scales

Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer; Lisspers, Karin; Malinovschi, Andrei; Melhus, Håkan; Ställberg, Björn; Nielsen, Elisabet I.

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Salo-Ahen, Outi M. H.; Alanko, Ida; Bhadane, Rajendra; Bonvin, Alexandre M. J. J.; Honorato, Rodrigo Vargas; Hossain, Md Shakhawath; Juffer, Andre H.; Kabedev, Aleksei; Lahtela-Kakkonen, Maija; Larsen, Anders Stottrup; Lescrinier, Eveline; Marimuthu, Parthiban; Mirza, Muhammad Usman; Mustafa, Ghulam; Nunes-Alves, Ariane; Pantsar, Tatu; Saadabadi, Atefeh; Singaravelu, Kalaimathy; Vanmeert, Michiel

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

Johannesson, Jenny; Khan, Jamal; Hubert, Madlen; Teleki, Alexandra; Bergström, Christel

3D-printing of solid lipid tablets from emulsion gels

Alzayer, Reem; Svedin, Elin; Rizvi, Soha Aftab; Basheti, Iman; Chaar, Betty; Saini, Bandana

Pharmacists' experience of asthma management in culturally and linguistically diverse (CALD) patients

Hossain, Md Shakhawath; Kabedev, Aleksei

Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development

Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica; Gutiérrez-de-Terán, Hugo; Ablahad, Hanin; Hamid, Selin; Grönbladh, Alfhild; Spizzo, Iresha; Gaspari, Tracey A.; Widdop, Robert E.; Hallberg, Anders; Backlund, Maria; Leśniak, Anna; Hallberg, Mathias; Larhed, Mats

N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands

Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S.; Phillipson, Mia; Artursson, Per; Teleki, Alexandra

Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

Berg, Staffan; Krause, Julius; Björkbom, Anders; Walter, Katrin; Harun, Said; Granfeldt, Andreas; Janzén, David; Nunes, Sandro Filipe; Antonsson, Malin; Van Zuydam, Natalie; Skrtic, Stanko; Hugerth, Andreas; Weitschies, Werner; Davies, Nigel; Abrahamsson, Bertil; Bergström, Christel

In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

Kuentz, Martin; Bergström, Christel A.S.

Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

Matsson, Pär; Baranczewski, Pawel; Giacomini, Kathleen M.; Andersson, Tommy B.; Palm, Johan; Palm, Katrin; Charman, William N.; Bergström, Christel A.S.

A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

Kempen, Thomas; Bertilsson, Maria; Hadziosmanovic, Nermin; Lindner, Karl-Johan; Melhus, Håkan; Nielsen, Elisabet I.; Sulku, Johanna; Gillespie, Ulrika

Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Kabedev, Aleksei; Hossain, Shakhawath; Hubert, Madlen; Larsson, Per; Bergström, Christel A. S.

Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

Ibrahim, Moustafa M. A.; Redestad, Erik; Kjellsson, Maria C.

Optimal Designs for Model-Based Assessment of Insulin Sensitivity and Glucose Effectiveness.

Wellhagen, Gustaf J.; Karlsson, Mats O.; Kjellsson, Maria C.

Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data

Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria

Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1

Wright, Leah; Joyce, Paul; Barnes, Timothy J.; Lundmark, Richard; Bergström, Christel A. S.; Hubert, Madlen; Prestidge, Clive A.

A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics

Sou, Tomás; Bergström, Christel A. S.

Contemporary formulation development for inhaled pharmaceuticals

Wieslander, Håkan; Harrison, Philip J.; Skogberg, Gabriel; Jackson, Sonya; Fridén, Markus; Karlsson, Johan; Spjuth, Ola; Wählby, Carolina

Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images

Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef; Christensen, Hege; Andersson, Tommy B.; Artursson, Per

Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes

Ölander, Magnus; Wegler, Christine; Flörkemeier, Inken; Treyer, Andrea; Handin, Niklas; Pedersen, Jenny M.; Vildhede, Anna; Mateus, André; LeCluyse, Edward L.; Urdzik, Jozef; Artursson, Per

Hepatocyte size fractionation allows dissection of human liver zonation

Chasseloup, Estelle; Yngman, Gunnar; Karlsson, Mats

Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both?

Jowkar, Nima; Fjeldso, Nina; Norgaard, Lotte Stig; Kälvemark Sporrong, Sofia; Jacobsen, Ramune; Kaae, Susanne

A Presentation of Central Communication Aspects in the Patient-Provider Relationship-Potential Learnings for Community Pharmacists

Wang, Zhigang; Dreesen, Erwin

Therapeutic drug monitoring of anti-tumor necrosis factor agents: lessons learned and remaining issues

Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E; Hooker, Andrew; Rostami-Hodjegan, Amin; Schmidt, Stephan; Suarez-Sharp, Sandra; Lukacova, Viera; Fang, Lanyan; Zhao, Liang

Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.

Ueckert, Sebastian; Karlsson, Mats

Improved numerical stability for the bounded integer model

Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z; Houston, J Brian; Kansy, Manfred; Kerns, Edward H; Lennernäs, Hans; Smith, Dennis A; Sugano, Kiyohiko

The Critical Role of Passive Permeability in Designing Successful Drugs

Senek, Marina; Nyholm, Dag; Nielsen, Elisabet I.

Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism

Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria; Ercan, Onur; Grinberga, Solveiga; Cao, Sha; Giachou, Paraskevi; Petersson, Anna; Tomczak, Magdalena; Urbas, Malgorzata; Zabicka, Dorota; Vingsbo Lundberg, Carina; Hughes, Diarmaid; Hobbie, Sven N; Friberg, Lena E

Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.

Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna; Shariatgorji, Reza; Haldimann, Klara; Platzack, Björn; Hughes, Diarmaid; Andrén, Per E; Böttger, Erik C; Friberg, Lena E; Hobbie, Sven N

Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.

Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan; Melhus, Håkan; Nielsen, Elisabet I.; Sulku, Johanna; Gillespie, Ulrika

Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.

Linnér, Love; Eriksson, Irene; Persson, Marie; Wettermark, Björn

Forecasting drug utilization and expenditure: ten years of experience in Stockholm.

Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J.; Camara, Miguel; Bergström, Christel

Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions

Druedahl, Louise C.; Almarsdottir, Anna Birna; Kälvemark Sporrong, Sofia; De Bruin, Marie Louise; Hoogland, Hans; Minssen, Timo; van de Weert, Marco; Kesselheim, Aaron S.; Sarpatwari, Ameet

A qualitative study of biosimilar manufacturer and regulator perceptions on intellectual property and abbreviated approval pathways

Schmidt-Mende, Katharina; Andersen, Morten; Wettermark, Björn; Hasselstrom, Jan

Drug-disease interactions in Swedish senior primary care patients were dominated by non-steroid anti-inflammatory drugs and hypertension - a population-based registry study

Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran; Soderhall, Arvid; Hellström, Per M.; Lennernäs, Hans

Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity

Ravandeh, M.; Kahlert, H.; Jablonowski, H.; Lackmann, J. -W; Striesow, J.; Agmo Hernández, Víctor; Wende, K.

A combination of electrochemistry and mass spectrometry to monitor the interaction of reactive species with supported lipid bilayers

Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik

Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Hansson, Per

Volume Transition and Phase Coexistence in Polyelectrolyte Gels Interacting with Amphiphiles and Proteins

Ekheden, Isabella; Ebrahim, Fereshte; olafsdottir, Halla; Raaschou, Pauline; Wettermark, Björn; Henriksson, Roger; Ye, Weimin

Survival of esophageal and gastric cancer patients with adjuvant and palliative chemotherapy-a retrospective analysis of a register-based patient cohort

Bergström, Christel; Llinas, Antonio

Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per

Cell-type-resolved proteomic analysis of the human liver

El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.

Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver; Höök, Fredrik; Larsson, Per; Bergström, Christel A. S.

Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath; Larsson, Per; Bergström, Christel; Höök, Fredrik

TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

An, Junxue; Forchheimer, Daniel; Savmarker, Jonas; Brulls, Mikael; Frenning, Göran

Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles

Teleki, Alexandra; Nylander, Olivia; Bergström, Christel

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Norinder, Ulf; Spjuth, Ola; Svensson, Fredrik

Using Predicted Bioactivity Profiles to Improve Predictive Modeling

Sinko, Patrick D.; Harris, Sarah; Salehi, Niloufar; Meyer, Pamela J.; Amidon, Gordon L.; Amidon, Gregory E.

Ultrathin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies

Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik

MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.

Dahlgren, David; Lennernäs, Hans

Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective

Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P.; Butler, J.; Holm, R.; Langguth, P.; Lindahl, A.; Muellertz, A.; Pepin, X.; Rostami-Hodjegan, A.; Sjögren, Erik; Berntsson, M.; Lennernäs, Hans

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran

Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling

Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona; Larsson, Johanna; Sandberg, Lars; Sahlberg, Sara Haggblad; Qian, Weixing; Gullberg, Hjalmar; Garg, Neeraj; Gustavsson, Anna-Lena; Haraldsson, Martin; Lane, David; Yngve, Ulrika; Lain, Sonia

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability