Department of Pharmacy

Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per

Global variability analysis of mRNA and protein concentrations across and within human tissues

Ilyas, Humaira; Kim, JaeWoong; Lee, DongKuk; Malmsten, Martin; Bhunia, Anirban

Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism

Norling, Karin; Bernasconi, Valentina; Agmo Hernandez, Victor; Parveen, Nagma; Edwards, Katarina; Lycke, Nils Y; Höök, Fredrik; Bally, Marta

Gel Phase 1,2-Distearoyl-sn-glycero-3-phosphocholine-Based Liposomes Are Superior to Fluid Phase Liposomes at Augmenting Both Antigen Presentation on Major Histocompatibility Complex Class II and Costimulatory Molecule Display by Dendritic Cells in Vitro

Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans

Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations

Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans

Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions

Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A.; Tannergren, C.; Sjögren, Erik; Sjöblom, Markus; Lennernäs, Hans

Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model

Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans

Rat intestinal drug permeability: A status report and summary of repeated determinations

Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik; Lennernäs, Hans

Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile

Reis, Pedro; Malmsten, Martin; Nydén, Magnus; Folmer, Britta; Holmberg, Krister

Interactions between Lipases and Amphiphiles at Interfaces

Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik; Hansson, Per; Lennernäs, Hans

Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality

Dahlgren, David; Lennernäs, Hans

Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A.; Lai, Yurong; Smith, Philip C.; Barber, Jill; Wisniewski, Jacek R.; Spellman, Daniel; Uchida, Yasuo; Zientek, Michael A.; Unadkat, Jashvant D.; Rostami-Hodjegan, Amin

Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier; Karlgren, Maria; Bergström, Christel; Nielsen, Carsten Uhd; Steffansen, Bente

The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin; Brouwers, Joachim; Augustijns, Patrick; Brandl, Martin; Bernkop-Schnürch, Andreas; Shrestha, Neha; Preat, Veronique; Müllertz, Anette; Bauer-Brandl, Annette; Jannin, Vincent

Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa; Rubin, Katarina; Lennernäs, Hans

Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model

Boge, Lukas; Browning, Kathryn L.; Nordström, Randi; Campana, Mario; Darngaard, Liv S. E.; Caous, Josefin Seth; Hellsing, Maja; Ringstad, Lovisa; Andersson, Martin

Peptide-Loaded Cubosomes Functioning as an Antimicrobial Unit against Escherichia coil

Charalabidis, Aggelos; Sfouni, Maria; Bergström, Christel; Macheras, Panos

The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit; Fowler, Stephen; Artursson, Per

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Edueng, Khadijah; Bergström, Christel; Gråsjö, Johan; Mahlin, Denny

Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

Edueng, Khadijah; Mahlin, Denny; Gråsjö, Johan; Nylander, Olivia; Thakrani, Manish; Bergström, Christel

Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

Zhang, Yuning; Andren, Oliver C. J.; Nordström, Randi; Fan, Yanmiao; Malmsten, Martin; Mongkhontreerat, Surinthra; Malkoch, Michael

Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics

Nordström, Randi; Andrén, Oliver C.J.; Singh, Shalini; Malkoch, Michael; Davoudi, Mina; Schmidtchen, Artur; Malmsten, Martin

Degradable dendritic nanogels as carriers for antimicrobial peptides

Bergström, Christel; Box, Karl; Holm, Rene; Matthews, Wayne; McAllister, Mark; Mullertz, Anette; Rades, Thomas; Schäfer, Kerstin J.; Teleki, Alexandra

Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

Thunander Sundbom, Lena; Hedborg, Kerstin

Association between prescribed antidepressants and other prescribed drugs differ by gender: a nationwide register-based study in Sweden

Bergström, Christel A.S.; Avdeef, Alex

Perspectives in solubility measurement and interpretation

Häffner, Sara Malekkhaiat; Nyström, Lina; Browning, Kathryn L.; Nielsen, Hanne Mörck; Strömstedt, Adam A.; van der Plas, Mariena J. A.; Schmidtchen, Artur; Malmsten, Martin

Interaction of Laponite with Membrane Components - Consequences for Bacterial Aggregation and Infection Confinement

Mohid, Sk Abdul; Ghorai, Arup; Ilyas, Humaira; Mroue, Kamal H.; Narayanan, Gomathy; Sarkar, Abhisek; Ray, Samit K.; Biswas, Kaushik; Bera, Amal Kanti; Malmsten, Martin; Midya, Anupam; Bhunia, Anirban

Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy

Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre; An, Junxue; Alderborn, Göran

Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model

El-Serafi, Ahmed T.; Sandeep, Divyasree; Abdallah, Sallam; Lozansson, Yasmin; Hamad, Moawiah; Khan, Amir A.

Paradoxical effects of the epigenetic modifiers 5-aza-deoxycytidine and suberoylanilide hydroxamic acid on adipogenesis

Hossain, Md Shakhawath; Kabedev, Aleksei; Parrow, Albin; Bergström, Christel; Larsson, Per

Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

Karlsson, Rose-Marie Pernilla; Larsson, Per Tomas; Hansson, Per; Wågberg, Lars

Thermodynamics of the Water-Retaining Properties of Cellulose-Based Networks

Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel; Artursson, Per

Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

Ölander, Magnus; Handin, Niklas; Artursson, Per

Image-based quantification of cell debris as a measure of apoptosis

Kishani, Saina; Escalante, Alfredo; Toriz, Guillermo; Vilaplana, Francisco; Gatenholm, Paul; Hansson, Per; Wagberg, Lars

Experimental and Theoretical Evaluation of the Solubility/Insolubility of Spruce Xylan (Arabino Glucuronoxylan)

Brekkan, Ari; Lopez-Lazaro, Luis; Plan, Elodie L.; Nyberg, Joakim; Kankanwadi, Suresh; Karlsson, Mats

Pharmacokinetic and Pharmacodynamic Sensitivity of Pegfilgrastim

Yang, Jing; An, Junxue; Tong, Lianpeng; Long, Baihua; Fan, Ting; Duan, Lele

Sulfur Coordination Effects on the Stability and Activity of a Ruthenium-Based Water Oxidation Catalyst

Keemink, Janneke; Martensson, Elin; Bergström, Christel

Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

Wisell, Kristin; Winblad, Ulrika; Kälvemark Sporrong, Sofia

Diversity as salvation?: A comparison of the diversity rationale in the Swedish pharmacy ownership liberalization reform and the primary care choice reform

Artursson, Per

Experimental approaches to understand intracellular based drug bioavailability

Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa; Ericsson, Hans; Lennernäs, Hans; Lundahl, Anna

Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions

Parra-Ortiz, Elisa; Browning, Kathryn L.; Damgaard, Liv S. E.; Nordström, Randi; Micciulla, Samantha; Bucciarelli, Saskia; Malmsten, Martin

Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes

Heimbach, Tycho; Suarez-Sharp, Sandra; Kakhi, Maziar; Holmstock, Nico; Olivares-Morales, Andres; Pepin, Xavier; Sjögren, Erik; Tsakalozou, Eleftheria; Seo, Paul; Li, Min; Zhang, Xinyuan; Lin, Ho-Pi; Montague, Timothy; Mitra, Amitava; Morris, Denise; Patel, Nikunjkumar; Kesisoglou, Filippos

Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report

Borro, Bruno C.; Bohr, Adam; Bucciarelli, Saskia; Boetker, Johan P.; Foged, Camilla; Rantanen, Jukka; Malmsten, Martin

Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design

Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M.; Hofmann, U.; Winter, S.; Neul, C.; Klein, K.; Zanger, U. M.; Artursson, Per; Schwab, M.

Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel; Levesque, Roger C.; Williams, Paul; Stocks, Michael; Camara, Miguel; Friberg, Lena E.; Bergström, Christel A. S.

Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

Alhalaweh, Amjad; Alzghoul, Ahmad; Bergström, Christel A. S.

Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions

Amidon, Gregory E.; Anderson, Bradley D.; Balthasar, Joseph P.; Bergström, Christel A.S.; Huang, Shiew-Mei; Kasting, Gerald; Kesisoglou, Filippos; Khinast, Johannes G.; Mager, Donald E.; Roberts, Christopher J.; Yu, Lian

Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Isaksson, Rebecka; Lindman, Jens; Wannberg, Johan; Sallander, Jessica; Backlund, Maria; Baraldi, Dhaniel; Widdop, Robert; Hallberg, Mathias; Åqvist, Johan; Gutierrez de Teran, Hugo; Gising, Johan; Larhed, Mats

A Series of Analogues to the AT₂R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

Hossain, Md Shakhawath; Berg, Staffan; Bergström, Christel; Larsson, Per

Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas; Urdzik, Jozef; Artursson, Per

A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

Alskär, Linda C.; Parrow, Albin; Keemink, Janneke; Pernilla, Johansson; Abrahamsson, Bertil; Bergström, Christel A. S.

Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

Nordström, Randi; Nyström, Lina; Ilyas, Humaira; Atreya, Hanudatta S; Borro, Bruno C; Malmsten, Martin

Microgels as carriers of antimicrobial peptides – effects of peptide PEGylation

Jonsson, Henrik; Öhman-Mägi, Caroline; Alderborn, Göran; Isaksson, Per; Frenning, Göran

Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load

Jonsson, Henrik; Alderborn, Göran; Frenning, Göran

Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles

Keemink, Janneke; Bergström, Christel A. S.

Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S.; Artursson, Per

CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

Keemink, Janneke; Deferm, Neel; De Bruyn, Tom; Augustijns, Patrick; Bouillon, Thomas; Annaert, Pieter

Effect of Cryopreservation on Enzyme and Transporter Activities in Suspended and Sandwich Cultured Rat Hepatocytes

Malmsten, Martin; Zauscher, Stefan

Editorial overview: Colloids and surfaces in biology

Häffner, Sara Malekkhaiat; Malmsten, Martin

Influence of self-assembly on the performance of antimicrobial peptides

Nyström, Lina; Malmsten, Martin

Membrane interactions and cell selectivity of amphiphilic anticancer peptides

Visnes, Torkild; Cazares-Korner, Armando; Hao, Wenjing; Wallner, Olov; Masuyer, Geoffrey; Loseva, Olga; Mortusewicz, Oliver; Wiita, Elisee; Sarno, Antonio; Manoilov, Aleksandr; Astorga-Wells, Juan; Jemth, Ann-Sofie; Pan, Lang; Sanjiv, Kumar; Karsten, Stella; Gokturk, Camilla; Grube, Maurice; Homan, Evert J.; Hanna, Bishoy M. F.; Paulin, Cynthia B. J.; Pham, Therese; Rasti, Azita; Berglund, Ulrika Warpman; von Nicolai, Catharina; Benitez-Buelga, Carlos; Koolmeister, Tobias; Ivanic, Dag; Iliev, Petar; Scobie, Martin; Krokan, Hans E.; Baranczewski, Pawel; Artursson, Per; Altun, Mikael; Jensen, Annika Jenmalm; Kalderen, Christina; Ba, Xueqing; Zubarev, Roman A.; Stenmark, Pal; Boldogh, Istvan; Helleday, Thomas

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Andersson, Martin; Hansson, Per

Binding of Lysozyme to Spherical Poly(styrenesulfonate) Gels

Guo, Yingying; Chu, Xiaoyan; Parrott, Neil J.; Brouwer, Kim L. R.; Hsu, Vicky; Nagar, Swati; Matsson, Pär; Sharma, Pradeep; Snoeys, Jan; Sugiyama, Yuichi; Tatosian, Daniel; Unadkat, Jashvant D.; Huang, Shiew-Mei; Galetin, Aleksandra

Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches

Schlessinger, Avner; Welch, Matthew A.; van Vlijmen, Herman; Korzekwa, Ken; Swaan, Peter W.; Matsson, Pär

Molecular Modeling of Drug-Transporter Interactions-An International Transporter Consortium Perspective

Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa P.; Ericsson, Hans; Lennernäs, Hans; Lundahl, Anna

Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions

Holdbrook, Daniel A.; Singh, Shalini; Choong, Yeu Khai; Petrlova, Jitka; Malmsten, Martin; Bond, Peter J.; Verma, Navin Kumar; Schmidtchen, Artur; Saravanan, Rathi

Influence of pH on the activity of thrombin-derived antimicrobial peptides

Nordström, Randi; Nyström, Lina; Andren, Oliver; Malkoch, Michael; Umerska, Anita; Davoudi, Mina; Schmidtchen, Artur; Malmsten, Martin

Poly(acrylic acid) microgels as carriers for antimicrobial peptides

Hens, Bart; Al-Gousous, Jozef; Wang, Kai; Salehi, Niloufar; Ziff, Robert M.; Tsume, Yasuhiro; Bermejo, Marival; Paixao, Paulo; Brasseur, James G.; Yu, Alex; Talattof, Arjang; Benninghoff, Gail; Langguth, Peter; Lennernäs, Hans; Hasler, William L.; Marciani, Luca; Sun, Duxin; Amidon, Gregory E.; Dickens, Joseph; Shedden, Kerby; Lobenberg, Raimar; Amidon, Gordon L.

Summary of the In Vivo Predictive Dissolution (iPD) - Oral Drug Delivery (ODD) Conference 2018