Department of Pharmacy
We teach, research and collaborate with society on issues related to the development, manufacture and the use of drugs. Pharmacy is a broad area with boundaries to natural, social and engineering sciences.
SDDF
Research platform
Swedish Drug Delivery Platform
UDOPP
Research platform
Uppsala University Drug Optimization and Pharmaceutical Profiling platform
Alumn
Alumni association
News
- ERC "Proof of Concept Grant" awarded to Christel Bergström in 3rd round 2019 2020-01-10
- Program for the 10th Symposium on Pharmaceutical Profiling in Drug Discovery and Development 2020-01-10
- Shno Asad awarded best poster prize at ICONAN 2019 2019-10-23
- Professor Hans Lennernäs has been awarded the Swedish royal academy of sciences Thuréusprize 2019-09-04
- Christel Bergström interviewed by Swedish TV and radio news about 3D-printing for pediatric care 2019-08-16
Calendar
Publications
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Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per
Global variability analysis of mRNA and protein concentrations across and within human tissues
2020
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Kulen, Martina; Nunez-Otero, Carlos; Cairns, Andrew G.; Silver, Jim; Lindgren, Anders E. G.; Wede, Emma; Singh, Pardeep; Vielfort, Katarina; Bahnan, Wael; Good, James A. D.; Svensson, Richard; Bergström, Sven; Gylfe, Åsa; Almqvist, Fredrik
Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors
2019
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Kishani, Saina; Vilaplana, Francisco; Ruda, Marcus; Hansson, Per; Wågberg, Lars
Influence of Solubility on the Adsorption of Different Xyloglucan Fractions at Cellulose–Water Interfaces
2019
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Malekkhaiat Häffner, Sara; Nyström, Lina; Strömstedt, Adam A.; Li, Li; van der Plas, Mariena J A; Malmsten, Martin
Nanoclay-induced bacterial flocculation for infection confinement.
2019
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Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär; Artursson, Per
A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))
2019
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Sjögren, Erik; Stahle, Lars; Quiding, Hans; Jonzon, Bror; Halldin, Magnus M.; Sundgren, Anna K.
The effect of intradermal microdosing of a transient receptor potential cation channel subfamily V member 1 antagonist on heat evoked pain and thermal thresholds in normal and ultraviolet-C exposed skin in healthy volunteers
2019
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Ilyas, Humaira; Kim, JaeWoong; Lee, DongKuk; Malmsten, Martin; Bhunia, Anirban
Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism
2019
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Norling, Karin; Bernasconi, Valentina; Agmo Hernandez, Victor; Parveen, Nagma; Edwards, Katarina; Lycke, Nils Y; Höök, Fredrik; Bally, Marta
Gel Phase 1,2-Distearoyl-sn-glycero-3-phosphocholine-Based Liposomes Are Superior to Fluid Phase Liposomes at Augmenting Both Antigen Presentation on Major Histocompatibility Complex Class II and Costimulatory Molecule Display by Dendritic Cells in Vitro
2019
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Dahlgren, David; Sjöblom, Markus; Lennernäs, Hans
Intestinal absorption-modifying excipients: A current update on preclinical in vivo evaluations
2019
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Roos, Carl; Dahlgren, David; Sjögren, Erik; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans
Effects of absorption-modifying excipients on jejunal drug absorption in simulated fasted and fed luminal conditions
2019
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Dahlgren, David; Roos, Carl; Peters, Karsten; Lundqvist, A.; Tannergren, C.; Sjögren, Erik; Sjöblom, Markus; Lennernäs, Hans
Evaluation of drug permeability calculation based on luminal disappearance and plasma appearance in the rat single-pass intestinal perfusion model
2019
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Dubbelboer, Ilse R; Dahlgren, David; Sjögren, Erik; Lennernäs, Hans
Rat intestinal drug permeability: A status report and summary of repeated determinations
2019
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Dubbelboer, Ilse R; Pavlovic, Natasa; Heindryckx, Femke; Sjögren, Erik; Lennernäs, Hans
Liver Cancer Cell Lines Treated with Doxorubicin under Normoxia and Hypoxia: Cell Viability and Oncologic Protein Profile
2019
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Reis, Pedro; Malmsten, Martin; Nydén, Magnus; Folmer, Britta; Holmberg, Krister
Interactions between Lipases and Amphiphiles at Interfaces
2019
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Ahnfelt, Emelie; Degerstedt, Oliver; Lilienberg, Elsa; Sjögren, Erik; Hansson, Per; Lennernäs, Hans
Lipiodol-based emulsions used for transarterial chemoembolization and drug delivery: Effects of composition on stability and product quality
2019
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Dahlgren, David; Lennernäs, Hans
Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches
2019
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Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A.; Lai, Yurong; Smith, Philip C.; Barber, Jill; Wisniewski, Jacek R.; Spellman, Daniel; Uchida, Yasuo; Zientek, Michael A.; Unadkat, Jashvant D.; Rostami-Hodjegan, Amin
Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper
2019
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Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier; Karlgren, Maria; Bergström, Christel; Nielsen, Carsten Uhd; Steffansen, Bente
The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach
2019
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Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin; Brouwers, Joachim; Augustijns, Patrick; Brandl, Martin; Bernkop-Schnürch, Andreas; Shrestha, Neha; Preat, Veronique; Müllertz, Anette; Bauer-Brandl, Annette; Jannin, Vincent
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems
2019
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Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.
Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?
2019
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Eriksson, Johanna; Thorn, Helena; Sjögren, Erik; Holmsten, Lisa; Rubin, Katarina; Lennernäs, Hans
Pulmonary Dissolution of Poorly Soluble Compounds Studied in an ex Vivo Rat Lung Model
2019
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Boge, Lukas; Browning, Kathryn L.; Nordström, Randi; Campana, Mario; Darngaard, Liv S. E.; Caous, Josefin Seth; Hellsing, Maja; Ringstad, Lovisa; Andersson, Martin
Peptide-Loaded Cubosomes Functioning as an Antimicrobial Unit against Escherichia coil
2019
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Charalabidis, Aggelos; Sfouni, Maria; Bergström, Christel; Macheras, Panos
The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines
2019
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Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit; Fowler, Stephen; Artursson, Per
Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies
2019
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Edueng, Khadijah; Bergström, Christel; Gråsjö, Johan; Mahlin, Denny
Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties
2019
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Edueng, Khadijah; Mahlin, Denny; Gråsjö, Johan; Nylander, Olivia; Thakrani, Manish; Bergström, Christel
Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage
2019
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Zhang, Yuning; Andren, Oliver C. J.; Nordström, Randi; Fan, Yanmiao; Malmsten, Martin; Mongkhontreerat, Surinthra; Malkoch, Michael
Off-Stoichiometric Thiol-Ene Chemistry to Dendritic Nanogel Therapeutics
2019
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Nordström, Randi; Andrén, Oliver C.J.; Singh, Shalini; Malkoch, Michael; Davoudi, Mina; Schmidtchen, Artur; Malmsten, Martin
Degradable dendritic nanogels as carriers for antimicrobial peptides
2019
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Bergström, Christel; Box, Karl; Holm, Rene; Matthews, Wayne; McAllister, Mark; Mullertz, Anette; Rades, Thomas; Schäfer, Kerstin J.; Teleki, Alexandra
Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects
2019
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Thunander Sundbom, Lena; Hedborg, Kerstin
Association between prescribed antidepressants and other prescribed drugs differ by gender: a nationwide register-based study in Sweden
2019
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Bergström, Christel A.S.; Avdeef, Alex
Perspectives in solubility measurement and interpretation
2019
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Häffner, Sara Malekkhaiat; Nyström, Lina; Browning, Kathryn L.; Nielsen, Hanne Mörck; Strömstedt, Adam A.; van der Plas, Mariena J. A.; Schmidtchen, Artur; Malmsten, Martin
Interaction of Laponite with Membrane Components - Consequences for Bacterial Aggregation and Infection Confinement
2019
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Mohid, Sk Abdul; Ghorai, Arup; Ilyas, Humaira; Mroue, Kamal H.; Narayanan, Gomathy; Sarkar, Abhisek; Ray, Samit K.; Biswas, Kaushik; Bera, Amal Kanti; Malmsten, Martin; Midya, Anupam; Bhunia, Anirban
Application of tungsten disulfide quantum dot-conjugated antimicrobial peptides in bio-imaging and antimicrobial therapy
2019
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Rudén, Jonas; Frenning, Göran; Bramer, Tobias; Thalberg, Kyrre; An, Junxue; Alderborn, Göran
Linking carrier morphology to the powder mechanics of adhesive mixtures for dry powder inhalers via a blend-state model
2019
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El-Serafi, Ahmed T.; Sandeep, Divyasree; Abdallah, Sallam; Lozansson, Yasmin; Hamad, Moawiah; Khan, Amir A.
Paradoxical effects of the epigenetic modifiers 5-aza-deoxycytidine and suberoylanilide hydroxamic acid on adipogenesis
2019
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Hossain, Md Shakhawath; Kabedev, Aleksei; Parrow, Albin; Bergström, Christel; Larsson, Per
Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning
2019
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Karlsson, Rose-Marie Pernilla; Larsson, Per Tomas; Hansson, Per; Wågberg, Lars
Thermodynamics of the Water-Retaining Properties of Cellulose-Based Networks
2019
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Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel; Artursson, Per
Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations
2019
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Ölander, Magnus; Handin, Niklas; Artursson, Per
Image-based quantification of cell debris as a measure of apoptosis
2019
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Kishani, Saina; Escalante, Alfredo; Toriz, Guillermo; Vilaplana, Francisco; Gatenholm, Paul; Hansson, Per; Wagberg, Lars
Experimental and Theoretical Evaluation of the Solubility/Insolubility of Spruce Xylan (Arabino Glucuronoxylan)
2019
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Brekkan, Ari; Lopez-Lazaro, Luis; Plan, Elodie L.; Nyberg, Joakim; Kankanwadi, Suresh; Karlsson, Mats
Pharmacokinetic and Pharmacodynamic Sensitivity of Pegfilgrastim
2019
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Yang, Jing; An, Junxue; Tong, Lianpeng; Long, Baihua; Fan, Ting; Duan, Lele
Sulfur Coordination Effects on the Stability and Activity of a Ruthenium-Based Water Oxidation Catalyst
2019
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Keemink, Janneke; Martensson, Elin; Bergström, Christel
Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro
2019
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Wisell, Kristin; Winblad, Ulrika; Kälvemark Sporrong, Sofia
Diversity as salvation?: A comparison of the diversity rationale in the Swedish pharmacy ownership liberalization reform and the primary care choice reform
2019
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Artursson, Per
Experimental approaches to understand intracellular based drug bioavailability
2019
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Garcia, Luna Prieto; Janzen, David; Kanebratt, Kajsa; Ericsson, Hans; Lennernäs, Hans; Lundahl, Anna
Physiologically based pharmacokinetic model predictions of ivosidenib (AG-120) as a victim and perpetrator of drug–drug interactions
2019
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Parra-Ortiz, Elisa; Browning, Kathryn L.; Damgaard, Liv S. E.; Nordström, Randi; Micciulla, Samantha; Bucciarelli, Saskia; Malmsten, Martin
Effects of oxidation on the physicochemical properties of polyunsaturated lipid membranes
2019
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Heimbach, Tycho; Suarez-Sharp, Sandra; Kakhi, Maziar; Holmstock, Nico; Olivares-Morales, Andres; Pepin, Xavier; Sjögren, Erik; Tsakalozou, Eleftheria; Seo, Paul; Li, Min; Zhang, Xinyuan; Lin, Ho-Pi; Montague, Timothy; Mitra, Amitava; Morris, Denise; Patel, Nikunjkumar; Kesisoglou, Filippos
Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link: a Workshop Summary Report
2019
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Borro, Bruno C.; Bohr, Adam; Bucciarelli, Saskia; Boetker, Johan P.; Foged, Camilla; Rantanen, Jukka; Malmsten, Martin
Microfluidics-based self-assembly of peptide-loaded microgels: Effect of three dimensional (3D) printed micromixer design
2019
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Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M.; Hofmann, U.; Winter, S.; Neul, C.; Klein, K.; Zanger, U. M.; Artursson, Per; Schwab, M.
Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver
2019
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Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel; Levesque, Roger C.; Williams, Paul; Stocks, Michael; Camara, Miguel; Friberg, Lena E.; Bergström, Christel A. S.
Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection
2019
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Alhalaweh, Amjad; Alzghoul, Ahmad; Bergström, Christel A. S.
Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions
2019
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Amidon, Gregory E.; Anderson, Bradley D.; Balthasar, Joseph P.; Bergström, Christel A.S.; Huang, Shiew-Mei; Kasting, Gerald; Kesisoglou, Filippos; Khinast, Johannes G.; Mager, Donald E.; Roberts, Christopher J.; Yu, Lian
Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling
2019
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Isaksson, Rebecka; Lindman, Jens; Wannberg, Johan; Sallander, Jessica; Backlund, Maria; Baraldi, Dhaniel; Widdop, Robert; Hallberg, Mathias; Åqvist, Johan; Gutierrez de Teran, Hugo; Gising, Johan; Larhed, Mats
A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode
2019
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Hossain, Md Shakhawath; Berg, Staffan; Bergström, Christel; Larsson, Per
Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation
2019
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Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per
Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking
2019
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Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas; Urdzik, Jozef; Artursson, Per
A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes
2019
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Alskär, Linda C.; Parrow, Albin; Keemink, Janneke; Pernilla, Johansson; Abrahamsson, Bertil; Bergström, Christel A. S.
Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?
2019
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Nordström, Randi; Nyström, Lina; Ilyas, Humaira; Atreya, Hanudatta S; Borro, Bruno C; Malmsten, Martin
Microgels as carriers of antimicrobial peptides – effects of peptide PEGylation
2019
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Jonsson, Henrik; Öhman-Mägi, Caroline; Alderborn, Göran; Isaksson, Per; Frenning, Göran
Crack nucleation and propagation in microcrystalline-cellulose based granules subject to uniaxial and triaxial load
2019
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Jonsson, Henrik; Alderborn, Göran; Frenning, Göran
Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial experiments on single particles
2019
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Keemink, Janneke; Bergström, Christel
Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations
2018
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Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S.; Artursson, Per
CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box
2018
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Keemink, Janneke; Deferm, Neel; De Bruyn, Tom; Augustijns, Patrick; Bouillon, Thomas; Annaert, Pieter
Effect of Cryopreservation on Enzyme and Transporter Activities in Suspended and Sandwich Cultured Rat Hepatocytes
2018
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Malmsten, Martin; Zauscher, Stefan
Editorial overview: Colloids and surfaces in biology
2018
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Häffner, Sara Malekkhaiat; Malmsten, Martin
Influence of self-assembly on the performance of antimicrobial peptides
2018
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Nyström, Lina; Malmsten, Martin
Membrane interactions and cell selectivity of amphiphilic anticancer peptides
2018
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Visnes, Torkild; Cazares-Korner, Armando; Hao, Wenjing; Wallner, Olov; Masuyer, Geoffrey; Loseva, Olga; Mortusewicz, Oliver; Wiita, Elisee; Sarno, Antonio; Manoilov, Aleksandr; Astorga-Wells, Juan; Jemth, Ann-Sofie; Pan, Lang; Sanjiv, Kumar; Karsten, Stella; Gokturk, Camilla; Grube, Maurice; Homan, Evert J.; Hanna, Bishoy M. F.; Paulin, Cynthia B. J.; Pham, Therese; Rasti, Azita; Berglund, Ulrika Warpman; von Nicolai, Catharina; Benitez-Buelga, Carlos; Koolmeister, Tobias; Ivanic, Dag; Iliev, Petar; Scobie, Martin; Krokan, Hans E.; Baranczewski, Pawel; Artursson, Per; Altun, Mikael; Jensen, Annika Jenmalm; Kalderen, Christina; Ba, Xueqing; Zubarev, Roman A.; Stenmark, Pal; Boldogh, Istvan; Helleday, Thomas
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation
2018
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Andersson, Martin; Hansson, Per
Binding of Lysozyme to Spherical Poly(styrenesulfonate) Gels
2018
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Guo, Yingying; Chu, Xiaoyan; Parrott, Neil J.; Brouwer, Kim L. R.; Hsu, Vicky; Nagar, Swati; Matsson, Pär; Sharma, Pradeep; Snoeys, Jan; Sugiyama, Yuichi; Tatosian, Daniel; Unadkat, Jashvant D.; Huang, Shiew-Mei; Galetin, Aleksandra
Advancing Predictions of Tissue and Intracellular Drug Concentrations Using In Vitro, Imaging and Physiologically Based Pharmacokinetic Modeling Approaches
2018