Department of Pharmacy
We teach, research and collaborate with society on issues related to the development, manufacture and the use of drugs. Pharmacy is a broad area with boundaries to natural, social and engineering sciences.
SweDeliver
New competence center
Academia and industry shaping the future of drug delivery
UDOPP
Research platform
Uppsala University Drug Optimization and Pharmaceutical Profiling platform
Alumn
Alumni association
News
- Now hiring: Researcher in molecular pharmaceutics 2021-04-07
- Now hiring: Post-doc for project about lipid nanoparticles for oral drug delivery 2021-04-07
- Drug Delivery Group paper highlighted in J Pharm Sci's "Most Original and Most Significant Scientific Findings" 2021-03-29
- Summary of the completed "Intestinanos" project published on CORDIS 2021-03-11
- Visit the Department of Pharmacy virtual booth at this year's SciFest exhibition 2021-02-26
Calendar
Publications
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Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer; Lisspers, Karin; Malinovschi, Andrei; Melhus, Håkan; Ställberg, Björn; Nielsen, Elisabet I.
Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
2021
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Salo-Ahen, Outi M. H.; Alanko, Ida; Bhadane, Rajendra; Bonvin, Alexandre M. J. J.; Honorato, Rodrigo Vargas; Hossain, Md Shakhawath; Juffer, Andre H.; Kabedev, Aleksei; Lahtela-Kakkonen, Maija; Larsen, Anders Stottrup; Lescrinier, Eveline; Marimuthu, Parthiban; Mirza, Muhammad Usman; Mustafa, Ghulam; Nunes-Alves, Ariane; Pantsar, Tatu; Saadabadi, Atefeh; Singaravelu, Kalaimathy; Vanmeert, Michiel
Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development
2021
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Alzayer, Reem; Svedin, Elin; Rizvi, Soha Aftab; Basheti, Iman; Chaar, Betty; Saini, Bandana
Pharmacists' experience of asthma management in culturally and linguistically diverse (CALD) patients
2021
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Hossain, Md Shakhawath; Kabedev, Aleksei
Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development
2021
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Wannberg, Johan; Gising, Johan; Lindman, Jens; Salander, Jessica; Gutiérrez-de-Terán, Hugo; Ablahad, Hanin; Hamid, Selin; Grönbladh, Alfhild; Spizzo, Iresha; Gaspari, Tracey A.; Widdop, Robert E.; Hallberg, Anders; Backlund, Maria; Leśniak, Anna; Hallberg, Mathias; Larhed, Mats
N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands
2021
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Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S.; Phillipson, Mia; Artursson, Per; Teleki, Alexandra
Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
2021
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Berg, Staffan; Krause, Julius; Björkbom, Anders; Walter, Katrin; Harun, Said; Granfeldt, Andreas; Janzén, David; Nunes, Sandro Filipe; Antonsson, Malin; Van Zuydam, Natalie; Skrtic, Stanko; Hugerth, Andreas; Weitschies, Werner; Davies, Nigel; Abrahamsson, Bertil; Bergström, Christel
In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery
2021
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Kuentz, Martin; Bergström, Christel A.S.
Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions
2021
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Matsson, Pär; Baranczewski, Pawel; Giacomini, Kathleen M.; Andersson, Tommy B.; Palm, Johan; Palm, Katrin; Charman, William N.; Bergström, Christel A.S.
A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research
2021
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Kabedev, Aleksei; Hossain, Shakhawath; Hubert, Madlen; Larsson, Per; Bergström, Christel A. S.
Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation
2021
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Ibrahim, Moustafa M. A.; Redestad, Erik; Kjellsson, Maria C
Optimal Designs for Model-Based Assessment of Insulin Sensitivity and Glucose Effectiveness.
2021
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Wellhagen, Gustaf J.; Karlsson, Mats O.; Kjellsson, Maria C.
Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data
2021
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Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria
Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
2021
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Wright, Leah; Joyce, Paul; Barnes, Timothy J.; Lundmark, Richard; Bergström, Christel A. S.; Hubert, Madlen; Prestidge, Clive A.
A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics
2021
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Sou, Tomás; Bergström, Christel A. S.
Contemporary formulation development for inhaled pharmaceuticals
2021
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Wieslander, Håkan; Harrison, Philip J.; Skogberg, Gabriel; Jackson, Sonya; Fridén, Markus; Karlsson, Johan; Spjuth, Ola; Wählby, Carolina
Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images
2021
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Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef; Christensen, Hege; Andersson, Tommy B; Artursson, Per
Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
2021
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Chasseloup, Estelle; Yngman, Gunnar; Karlsson, Mats
Comparison of covariate selection methods with correlated covariates: prior information versus data information, or a mixture of both?
2020
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Jowkar, Nima; Fjeldso, Nina; Norgaard, Lotte Stig; Kälvemark Sporrong, Sofia; Jacobsen, Ramune; Kaae, Susanne
A Presentation of Central Communication Aspects in the Patient-Provider Relationship-Potential Learnings for Community Pharmacists
2020
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Wang, Zhigang; Dreesen, Erwin
Therapeutic drug monitoring of anti-tumor necrosis factor agents: lessons learned and remaining issues
2020
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Svensson, Elin M
Probability of mycobactericidal activity of para-aminosalicylic acid with novel dosing regimens
2020
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Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E; Hooker, Andrew; Rostami-Hodjegan, Amin; Schmidt, Stephan; Suarez-Sharp, Sandra; Lukacova, Viera; Fang, Lanyan; Zhao, Liang
Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.
2020
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Arrington, Leticia; Ueckert, Sebastian; Ahamadi, Malidi; Macha, Sreeraj; Karlsson, Mats
Performance of longitudinal item response theory models in shortened or partial assessments.
2020
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Ueckert, Sebastian; Karlsson, Mats
Improved numerical stability for the bounded integer model
2020
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Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z; Houston, J Brian; Kansy, Manfred; Kerns, Edward H; Lennernäs, Hans; Smith, Dennis A; Sugano, Kiyohiko
The Critical Role of Passive Permeability in Designing Successful Drugs
2020
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Senek, Marina; Nyholm, Dag; Nielsen, Elisabet I.
Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism
2020
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Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria; Ercan, Onur; Grinberga, Solveiga; Cao, Sha; Giachou, Paraskevi; Petersson, Anna; Tomczak, Magdalena; Urbas, Malgorzata; Zabicka, Dorota; Vingsbo Lundberg, Carina; Hughes, Diarmaid; Hobbie, Sven N; Friberg, Lena E
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
2020
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Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna; Shariatgorji, Reza; Haldimann, Klara; Platzack, Björn; Hughes, Diarmaid; Andrén, Per E; Böttger, Erik C; Friberg, Lena E; Hobbie, Sven N
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
2020
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Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan; Melhus, Håkan; Nielsen, Elisabet I.; Sulku, Johanna; Gillespie, Ulrika
Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
2020
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Linnér, Love; Eriksson, Irene; Persson, Marie; Wettermark, Björn
Forecasting drug utilization and expenditure: ten years of experience in Stockholm.
2020
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Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J.; Camara, Miguel; Bergström, Christel
Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions
2020
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Druedahl, Louise C.; Almarsdottir, Anna Birna; Kälvemark Sporrong, Sofia; De Bruin, Marie Louise; Hoogland, Hans; Minssen, Timo; van de Weert, Marco; Kesselheim, Aaron S.; Sarpatwari, Ameet
A qualitative study of biosimilar manufacturer and regulator perceptions on intellectual property and abbreviated approval pathways
2020
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Schmidt-Mende, Katharina; Andersen, Morten; Wettermark, Björn; Hasselstrom, Jan
Drug-disease interactions in Swedish senior primary care patients were dominated by non-steroid anti-inflammatory drugs and hypertension - a population-based registry study
2020
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Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran; Soderhall, Arvid; Hellström, Per M.; Lennernäs, Hans
Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity
2020
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Ravandeh, M.; Kahlert, H.; Jablonowski, H.; Lackmann, J. -W; Striesow, J.; Agmo Hernández, Víctor; Wende, K.
A combination of electrochemistry and mass spectrometry to monitor the interaction of reactive species with supported lipid bilayers
2020
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Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik
Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling
2020
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Hansson, Per
Volume Transition and Phase Coexistence in Polyelectrolyte Gels Interacting with Amphiphiles and Proteins
2020
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Ekheden, Isabella; Ebrahim, Fereshte; olafsdottir, Halla; Raaschou, Pauline; Wettermark, Björn; Henriksson, Roger; Ye, Weimin
Survival of esophageal and gastric cancer patients with adjuvant and palliative chemotherapy-a retrospective analysis of a register-based patient cohort
2020
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Bergström, Christel; Llinas, Antonio
Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds
2020
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Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per
Cell-type-resolved proteomic analysis of the human liver
2020
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El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.
Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs
2020
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Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver; Höök, Fredrik; Larsson, Per; Bergström, Christel A. S.
Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers
2020
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Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.
Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization
2020
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Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath; Larsson, Per; Bergström, Christel; Höök, Fredrik
TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica
2020
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An, Junxue; Forchheimer, Daniel; Savmarker, Jonas; Brulls, Mikael; Frenning, Göran
Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles
2020
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Teleki, Alexandra; Nylander, Olivia; Bergström, Christel
Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
2020
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Norinder, Ulf; Spjuth, Ola; Svensson, Fredrik
Using Predicted Bioactivity Profiles to Improve Predictive Modeling
2020
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Sinko, Patrick D.; Harris, Sarah; Salehi, Niloufar; Meyer, Pamela J.; Amidon, Gordon L.; Amidon, Gregory E.
Ultrathin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies
2020
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Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik
MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.
2020
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Dahlgren, David; Lennernäs, Hans
Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
2020
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Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P.; Butler, J.; Holm, R.; Langguth, P.; Lindahl, A.; Muellertz, A.; Pepin, X.; Rostami-Hodjegan, A.; Sjögren, Erik; Berntsson, M.; Lennernäs, Hans
Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project
2020
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Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran
Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling
2020
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Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona; Larsson, Johanna; Sandberg, Lars; Sahlberg, Sara Haggblad; Qian, Weixing; Gullberg, Hjalmar; Garg, Neeraj; Gustavsson, Anna-Lena; Haraldsson, Martin; Lane, David; Yngve, Ulrika; Lain, Sonia
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
2020
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Lundsten, Sara; Hernandez, Victor Agmo; Gedda, Lars; Sarén, Tina; Brown, Christopher J.; Lane, David P.; Edwards, Katarina; Nestor, Marika
Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
2020
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Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H
Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
2020
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Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert
CG4928 is vital for renal function in fruit flies and membrane potential in cells: A first in-depth characterization of the putative Solute Carrier UNC93A
2020
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Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N.; Richardson, William; Lucanto, Simone; Oton, Eduard Vico; Qudus, Naim Ruhul; Mashabi, Alaa; Grossman, Scott; Ali, Sadiqur; Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Bergström, Christel; Halliday, Nigel; Mistry, Shailesh N.; Emsley, Jonas; Heeb, Stephan; Williams, Paul; Camara, Miguel; Stocks, Michael J.
Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa
2020
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Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo; Bergström, Christel; Neuhoff, Sibylle; Artursson, Per; Steffansen, Bente; Nielsen, Carsten Uhd
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
2020
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Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean; Strömme, Maria; Gogoll, A; Prestidge, Clive A; Bergström, Christel A. S.
In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
2020
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Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena
Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
2020
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Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena; Bergström, Christel
Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections
2020
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Nakai, Daisuke; Miyake, Masateru; Hashimoto, Ayako
Comparison of the Intestinal Drug Permeation and Accumulation Between Normal Human Intestinal Tissues and Human Intestinal Tissues With Ulcerative Colitis
2020
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Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael; Sjöblom, Markus; Lennernäs, Hans
Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
2020
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Borro, Bruno C.; Nordström, Randi; Malmsten, Martin
Microgels and hydrogels as delivery systems for antimicrobial peptides
2020
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Al-Tikriti, Yassir; Hansson, Per
Drug-Eluting Polyacrylate Microgels: Loading and Release of Amitriptyline
2020
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Hedge, Oliver; Bergström, Christel A. S.
Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations
2020
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Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean; Strömme, Maria; Bergström, Christel
An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
2020
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Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans
The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
2020
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Hubert, Madlen; Larsson, Elin; Lundmark, Richard
Keeping in touch with the membrane: protein- and lipid-mediated confinement of caveolae to the cell surface
2020
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Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E.; Bergström, Christel
Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties
2020