
Institutionen för farmaci
Vi undervisar, forskar och samverkar med samhället i frågor som rör utveckling, tillverkning och användning av läkemedel. Farmaciämnet är brett med gränsytor mot natur-, samhälls- och teknikvetenskap.
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Uppsala University Drug Optimization and Pharmaceutical Profiling platform
Alumn

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Nyheter
- Är du intresserad av att forska i sommar? 2021-01-11
- Alexandra Teleki tilldelad Europeiska forskningsrådets (ERC) konsolidatoranslag 2020-12-10
- 16.68 miljoner till forskning vid farmaceutiska fakulteten 2020-11-16
- Professor Per Artursson: Giant of Pharmaceutical Sciences 2020-11-11
- Doktorandtjänst inom läkemedelsexponering i kolon 2020-11-11
Kalendarium
Publikationer
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Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A S; Phillipson, Mia; Artursson, Per; Teleki, Alexandra
Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease.
2021
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Kabedev, Aleksei; Hossain, Shakhawath; Hubert, Madlen; Larsson, Per; Bergström, Christel A.S.
Molecular Dynamics Simulations Reveal Membrane Interactions for Poorly Water-Soluble Drugs: Impact of Bile Solubilization and Drug Aggregation
2021
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Ibrahim, Moustafa M A; Redestad, Erik; Kjellsson, Maria C
Optimal Designs for Model-Based Assessment of Insulin Sensitivity and Glucose Effectiveness.
2021
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Svensson, Elin M
Probability of mycobactericidal activity of para-aminosalicylic acid with novel dosing regimens
2020
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Lee, Jieon; Gong, Yuqing; Bhoopathy, Sid; DiLiberti, Charles E; Hooker, Andrew; Rostami-Hodjegan, Amin; Schmidt, Stephan; Suarez-Sharp, Sandra; Lukacova, Viera; Fang, Lanyan; Zhao, Liang
Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model-Based Bioequivalence.
2020
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Ueckert, Sebastian; Karlsson, Mats
Improved numerical stability for the bounded integer model.
2020
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Arrington, Leticia; Ueckert, Sebastian; Ahamadi, Malidi; Macha, Sreeraj; Karlsson, Mats
Performance of longitudinal item response theory models in shortened or partial assessments.
2020
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Larsson, Per; Kabedev, Aleksei; Hossain, Md Shakhawath; Hubert, Madlen
Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation
2020
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Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z; Houston, J Brian; Kansy, Manfred; Kerns, Edward H; Lennernäs, Hans; Smith, Dennis A; Sugano, Kiyohiko
The Critical Role of Passive Permeability in Designing Successful Drugs
2020
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Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria; Ercan, Onur; Grinberga, Solveiga; Cao, Sha; Giachou, Paraskevi; Petersson, Anna; Tomczak, Magdalena; Urbas, Malgorzata; Zabicka, Dorota; Vingsbo Lundberg, Carina; Hughes, Diarmaid; Hobbie, Sven N; Friberg, Lena E
Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.
2020
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Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna; Shariatgorji, Reza; Haldimann, Klara; Platzack, Björn; Hughes, Diarmaid; Andrén, Per E; Böttger, Erik C; Friberg, Lena E; Hobbie, Sven N
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
2020
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Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan; Melhus, Håkan; Nielsen, Elisabet I.; Sulku, Johanna; Gillespie, Ulrika
Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
2020
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Linnér, Love; Eriksson, Irene; Persson, Marie; Wettermark, Björn
Forecasting drug utilization and expenditure: ten years of experience in Stockholm.
2020
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Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J.; Camara, Miguel; Bergström, Christel
Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions
2020
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Nyman, Elin; Lindh, Maria; Lövfors, William; Simonsson, Christian; Persson, Alexander; Eklund, Daniel; Bäckström, Erica; Fridén, Markus; Cedersund, Gunnar
Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling.
2020
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Druedahl, Louise C.; Almarsdottir, Anna Birna; Kälvemark Sporrong, Sofia; De Bruin, Marie Louise; Hoogland, Hans; Minssen, Timo; van de Weert, Marco; Kesselheim, Aaron S.; Sarpatwari, Ameet
A qualitative study of biosimilar manufacturer and regulator perceptions on intellectual property and abbreviated approval pathways
2020
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Schmidt-Mende, Katharina; Andersen, Morten; Wettermark, Björn; Hasselstrom, Jan
Drug-disease interactions in Swedish senior primary care patients were dominated by non-steroid anti-inflammatory drugs and hypertension - a population-based registry study
2020
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Holmbäck, Ulf; Forslund, Anders; Gruden, Stefan; Alderborn, Göran; Soderhall, Arvid; Hellström, Per M.; Lennernäs, Hans
Effects of a novel combination of orlistat and acarbose on tolerability, appetite, and glucose metabolism in persons with obesity
2020
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Ravandeh, M.; Kahlert, H.; Jablonowski, H.; Lackmann, J. -W; Striesow, J.; Agmo Hernández, Víctor; Wende, K.
A combination of electrochemistry and mass spectrometry to monitor the interaction of reactive species with supported lipid bilayers
2020
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Eriksson, Johanna; Thorn, Helena; Lennernäs, Hans; Sjögren, Erik
Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling
2020
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Hansson, Per
Volume Transition and Phase Coexistence in Polyelectrolyte Gels Interacting with Amphiphiles and Proteins
2020
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Ekheden, Isabella; Ebrahim, Fereshte; olafsdottir, Halla; Raaschou, Pauline; Wettermark, Björn; Henriksson, Roger; Ye, Weimin
Survival of esophageal and gastric cancer patients with adjuvant and palliative chemotherapy-a retrospective analysis of a register-based patient cohort
2020
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Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria
Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.
2020
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Bergström, Christel; Llinas, Antonio
Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds
2020
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Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per
Cell-type-resolved proteomic analysis of the human liver
2020
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Sou, Tomás; Bergström, Christel A S
Contemporary formulation development for inhaled pharmaceuticals.
2020
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Wright, Leah; Joyce, Paul; Barnes, Timothy J; Lundmark, Richard; Bergström, Christel A S; Hubert, Madlen; Prestidge, Clive A
A comparison of chitosan, mesoporous silica and poly(lactic-co-glycolic) acid nanocarriers for optimising intestinal uptake of oral protein therapeutics.
2020
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El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.
Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs
2020
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Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver; Höök, Fredrik; Larsson, Per; Bergström, Christel A. S.
Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers
2020
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Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.
Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization
2020
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Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath; Larsson, Per; Bergström, Christel; Höök, Fredrik
TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica
2020
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An, Junxue; Forchheimer, Daniel; Savmarker, Jonas; Brulls, Mikael; Frenning, Göran
Nanoscale characterization of PEGylated phospholipid coatings formed by spray drying on silica microparticles
2020
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Teleki, Alexandra; Nylander, Olivia; Bergström, Christel
Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media
2020
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Norinder, Ulf; Spjuth, Ola; Svensson, Fredrik
Using Predicted Bioactivity Profiles to Improve Predictive Modeling
2020
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Sinko, Patrick D.; Harris, Sarah; Salehi, Niloufar; Meyer, Pamela J.; Amidon, Gordon L.; Amidon, Gregory E.
Ultrathin, Large-Area Membrane Diffusion Cell for pH-Dependent Simultaneous Dissolution and Absorption Studies
2020
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Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik
MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.
2020
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Dahlgren, David; Lennernäs, Hans
Antibody-Drug Conjugates and Targeted Treatment Strategies for Hepatocellular Carcinoma: A Drug-Delivery Perspective
2020
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Abrahamsson, B.; McAllister, M.; Augustijns, P.; Zane, P.; Butler, J.; Holm, R.; Langguth, P.; Lindahl, A.; Muellertz, A.; Pepin, X.; Rostami-Hodjegan, A.; Sjögren, Erik; Berntsson, M.; Lennernäs, Hans
Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project
2020
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Sarangi, Sohan; Thalberg, Kyrre; Frenning, Göran
Numerical modeling of collision of adhesive units: Stability and mechanical properties during handling
2020
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Popova, Gergana; Ladds, Marcus J. G. W.; Johansson, Lars; Saleh, Aljona; Larsson, Johanna; Sandberg, Lars; Sahlberg, Sara Haggblad; Qian, Weixing; Gullberg, Hjalmar; Garg, Neeraj; Gustavsson, Anna-Lena; Haraldsson, Martin; Lane, David; Yngve, Ulrika; Lain, Sonia
Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability
2020
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Lundsten, Sara; Hernandez, Victor Agmo; Gedda, Lars; Sarén, Tina; Brown, Christopher J.; Lane, David P.; Edwards, Katarina; Nestor, Marika
Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks
2020
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Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H
Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations
2020
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Ceder, Mikaela M.; Aggarwal, Tanya; Hosseini, Kimia; Maturi, Varun; Patil, Sourabh; Perland, Emelie; Williams, Michael J.; Fredriksson, Robert
CG4928 is vital for renal function in fruit flies and membrane potential in cells: A first in-depth characterization of the putative Solute Carrier UNC93A
2020
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Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N.; Richardson, William; Lucanto, Simone; Oton, Eduard Vico; Qudus, Naim Ruhul; Mashabi, Alaa; Grossman, Scott; Ali, Sadiqur; Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Bergström, Christel; Halliday, Nigel; Mistry, Shailesh N.; Emsley, Jonas; Heeb, Stephan; Williams, Paul; Camara, Miguel; Stocks, Michael J.
Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa
2020
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Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo; Bergström, Christel; Neuhoff, Sibylle; Artursson, Per; Steffansen, Bente; Nielsen, Carsten Uhd
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
2020
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Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean; Strömme, Maria; Gogoll, A; Prestidge, Clive A; Bergström, Christel A. S.
In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier
2020
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Eriksson, Johanna; Sjögren, Erik; Lennernäs, Hans; Thörn, Helena
Drug Absorption Parameters Obtained Using the Isolated Perfused Rat Lung Model Are Predictive of Rat In Vivo Lung Absorption
2020
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Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena; Bergström, Christel
Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections
2020
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Nakai, Daisuke; Miyake, Masateru; Hashimoto, Ayako
Comparison of the Intestinal Drug Permeation and Accumulation Between Normal Human Intestinal Tissues and Human Intestinal Tissues With Ulcerative Colitis
2020
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Dahlgren, David; Cano-Cebrian, Maria-Jose; Olander, Tobias; Hedeland, Mikael; Sjöblom, Markus; Lennernäs, Hans
Regional Intestinal Drug Permeability and Effects of Permeation Enhancers in Rat
2020
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Borro, Bruno C.; Nordström, Randi; Malmsten, Martin
Microgels and hydrogels as delivery systems for antimicrobial peptides
2020
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Wieslander, Håkan; Harrison, Philip J; Skogberg, Gabriel; Jackson, Sonya; Fridén, Marcus; Karlsson, Johan; Spjuth, Ola; Wählby, Carolina
Deep learning and conformal prediction for hierarchical analysis of large-scale whole-slide tissue images
2020
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Al-Tikriti, Yassir; Hansson, Per
Drug-Eluting Polyacrylate Microgels: Loading and Release of Amitriptyline
2020
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Hedge, Oliver; Bergström, Christel A. S.
Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations
2020
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Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean; Strömme, Maria; Bergström, Christel
An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems
2020
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Dahlgren, David; Sjöblom, Markus; Hedeland, Mikael; Lennernäs, Hans
The In Vivo Effect of Transcellular Permeation Enhancers on the Intestinal Permeability of Two Peptide Drugs Enalaprilat and Hexarelin
2020
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Hubert, Madlen; Larsson, Elin; Lundmark, Richard
Keeping in touch with the membrane: protein- and lipid-mediated confinement of caveolae to the cell surface
2020
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Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E.; Bergström, Christel
Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties
2020
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Bransford, Philip; Cook, Jack; Gupta, Manish; Haertter, Sebastian; He, Handan; Ju, Rob; Kanodia, Jitendra; Lennernäs, Hans; Lindley, David; Polli, James E.; Wenning, Larissa; Wu, Yunhui
ICH M9 Guideline in Development on Biopharmaceutics Classification System-Based Biowaivers: An Industrial Perspective from the IQ Consortium
2020
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Artursson, Per; Lundquist, Patrik
A new opening for orally taken peptide drugs
2020
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Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine; Angeles, Philip Carlo; Hjelmesaeth, Jöran; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege
A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity
2020
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Kishani, Saina; Vilaplana, Francisco; Ruda, Marcus; Hansson, Per; Wågberg, Lars
Influence of Solubility on the Adsorption of Different Xyloglucan Fractions at Cellulose–Water Interfaces
2020
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Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per
Global variability analysis of mRNA and protein concentrations across and within human tissues
2020
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Nordström, Randi; Browning, Kathryn L.; Parra-Ortiz, Elisa; Dangaard, Liv Sofia Elinor; Malekkhaiat-Häffner, Sara; Maestro, Armando; Campbell, Richard A.; Cooper, Joshaniel F. K.; Malmsten, Martin
Membrane Interactions of Antimicrobial Peptide-Loaded Microgels
2020
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Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida; Wisniewski, Jacek R; Hjelmesæth, Jøran; Åsberg, Anders; Jansson-Löfmark, Rasmus; Andersson, Tommy B; Artursson, Per
Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight
2020
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Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Ng, Adrian; O'Brien, Casey; Giannakis, Marios; Artursson, Per; Nygren, Peter; Cheong, Ian; Sjöblom, Tobias
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
2020
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Pazesh, Samaneh; Persson, Ann-Sofie; Alderborn, Göran
Atypical compaction behaviour of disordered lactose explained by a shift in type of compact fracture pattern
2019
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Lippert, Joerg; Burghaus, Rolf; Edginton, Andrea; Frechen, Sebastian; Karlsson, Mats; Kovar, Andreas; Lehr, Thorsten; Milligan, Peter; Nock, Valerie; Ramusovic, Sergej; Riggs, Matthew; Schaller, Stephan; Schlender, Jan; Schmidt, Stephan; Sevestre, Michael; Sjögren, Erik; Solodenko, Juri; Staab, Alexander; Teutonico, Donato
Open Systems Pharmacology Community-An Open Access, Open Source, Open Science Approach to Modeling and Simulation in Pharmaceutical Sciences
2019
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Lenhart, Vincent; Quodbach, Julian; Kleinebudde, Peter
Fibrillated Cellulose via High Pressure Homogenization: Analysis and Application for Orodispersible Films
2019
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Kulen, Martina; Nunez-Otero, Carlos; Cairns, Andrew G.; Silver, Jim; Lindgren, Anders E. G.; Wede, Emma; Singh, Pardeep; Vielfort, Katarina; Bahnan, Wael; Good, James A. D.; Svensson, Richard; Bergström, Sven; Gylfe, Åsa; Almqvist, Fredrik
Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors
2019