Publications

  • Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per

    Global variability analysis of mRNA and protein concentrations across and within human tissues

    Part of NAR genomics and bioinformatics, 2020.

    Open access
  • Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K. et al.

    A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

    Part of Drug Metabolism And Disposition, p. 8-17, 2020.

  • Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E. et al.

    Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

    Part of AAPS Journal, 2020.

    Open access
  • Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

    Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

    Part of Nature Communications, 2020.

    Open access
  • Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean et al.

    An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

    Part of European journal of pharmaceutics and biopharmaceutics, p. 21-29, 2020.

    Open access
  • Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena et al.

    Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

    Part of Molecular Pharmaceutics, p. 1458-1469, 2020.

  • Larsson, Per; Kneiszl, Rosita; Marklund, Erik

    MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all‐atom molecular dynamics simulations

    Part of Journal of Computational Chemistry, 2020.

  • Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

    Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

    Part of Pharmaceutics, 2020.

    Open access
  • Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N. et al.

    Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

    Part of Frontiers in Chemistry, 2020.

    Open access
  • Hedge, Oliver; Bergström, Christel A. S.

    Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

    Part of Pharmaceutical research, 2020.

    Open access
  • Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel et al.

    Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

    Part of Journal of Pharmaceutical Sciences, p. 630-640, 2019.

    Open access
  • Alhalaweh, Amjad; Alzghoul, Ahmad; Bergström, Christel A. S.

    Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions

    Part of Journal of Pharmaceutical Sciences, p. 252-259, 2019.

    Open access
  • Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M. et al.

    Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

    Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. S8-S8, 2019.

  • Amidon, Gregory E.; Anderson, Bradley D.; Balthasar, Joseph P.; Bergström, Christel A.S. et al.

    Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

    Part of Journal of Pharmaceutical Sciences, p. 2-7, 2019.

  • Artursson, Per

    Experimental approaches to understand intracellular based drug bioavailability

    Part of Drug Metabolism and Pharmacokinetics, p. S3-S3, 2019.

  • Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel et al.

    Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

    Part of Scientific Reports, 2019.

    Open access
  • Keemink, Janneke; Martensson, Elin; Bergström, Christel

    Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

    Part of Molecular Pharmaceutics, p. 921-930, 2019.

    Open access
  • Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

    A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

    Part of Archives of Toxicology, p. 819-829, 2019.

    Open access
  • Bergström, Christel A.S.; Avdeef, Alex

    Perspectives in solubility measurement and interpretation

    Part of ADMET AND DMPK, p. 88 88-105 105, 2019.

    Open access
  • Ölander, Magnus; Handin, Niklas; Artursson, Per

    Image-based quantification of cell debris as a measure of apoptosis

    Part of Analytical Chemistry, p. 5548-5552, 2019.

    Open access
  • Bergström, Christel; Box, Karl; Holm, Rene; Matthews, Wayne et al.

    Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

    Part of European journal of pharmaceutics and biopharmaceutics, p. 101-114, 2019.

  • Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

    Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

    Part of Journal of Proteome Research, p. 217-224, 2019.

    Open access
  • Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit et al.

    Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

    Part of AAPS Journal, 2019.

    Open access
  • Charalabidis, Aggelos; Sfouni, Maria; Bergström, Christel; Macheras, Panos

    The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

    Part of International Journal of Pharmaceutics, p. 264-281, 2019.

  • Alskär, Linda C.; Parrow, Albin; Keemink, Janneke; Pernilla, Johansson et al.

    Effect of lipids on absorption of carvedilol in dogs: Is coadministration of lipids as efficient as a lipid-based formulation?

    Part of Journal of Controlled Release, p. 90-100, 2019.

  • Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

    Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

    Part of Journal of Pharmaceutical Sciences, p. 1765-1771, 2019.

    Open access
  • Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin et al.

    Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

    Part of European Journal of Pharmaceutical Sciences, 2019.

    Open access
  • Edueng, Khadijah; Mahlin, Denny; Gråsjö, Johan; Nylander, Olivia et al.

    Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

    Part of Molecules, 2019.

    Open access
  • Alvebratt, Caroline; Denning, T.; Prestidge, Cliff; Bergström, Christel et al.

    Advanced methodologies to study in vitro digestion of a lipid-loaded mesoporous drug carrier

    Part of Preclinical Form and Formulation for Drug Discovery, Gordon Research Conference 2019, 2019.

  • Edueng, Khadijah; Bergström, Christel; Gråsjö, Johan; Mahlin, Denny

    Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

    Part of Pharmaceutics, 2019.

  • Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A. et al.

    Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

    Part of Clinical Pharmacology and Therapeutics, p. 525-543, 2019.

  • Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier et al.

    The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

    Part of Molecular Pharmaceutics, p. 4636-4650, 2019.

  • Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär et al.

    A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

    Part of Pharmaceutical research, 2019.

    Open access
  • Hossain, Md Shakhawath; Berg, Staffan; Bergström, Christel; Larsson, Per

    Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics Simulation

    Part of AAPS PharmSciTech, 2019.

    Open access
  • Hossain, Md Shakhawath; Kabedev, Aleksei; Parrow, Albin; Bergström, Christel et al.

    Molecular simulation as a computational pharmaceutics tool to predict drug solubility, solubilization processes and partitioning

    Part of European journal of pharmaceutics and biopharmaceutics, p. 46-55, 2019.

    Open access
  • Knijnenburg, Jesper T.N.; Posavec, Lidija; Teleki, Alexandra

    Chapter 4 - Nanostructured Minerals and Vitamins for Food Fortification and Food Supplementation

    Part of Nanomaterials for Food Applications, p. 63-98, 2019.

  • Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Padhan, Narendra et al.

    Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells

    Part of Genome Medicine, 2018.

  • Shrestha, Neha; Bouttefeux, Oriane; Vanvarenberg, Kevin; Lundquist, Patrik et al.

    The stimulation of GLP-1 secretion and delivery of GLP-1 agonists &ITvia&IT nanostructured lipid carriers

    Part of Nanoscale, p. 603-613, 2018.

  • Islam, Md. Koushikul; Strand, Mårten; Saleeb, Michael; Svensson, Richard et al.

    Anti-Rift Valley fever virus activity in vitro, pre-clinical pharmacokinetics and oral bioavailability of benzavir-2, a broad-acting antiviral compound

    Part of Scientific Reports, 2018.

    Open access
  • Bergström, Christel A S; Larsson, Per

    Computational prediction of drug solubility in water-based systems: qualitative and quantitative approaches used in the current drug discovery and development setting

    Part of International Journal of Pharmaceutics, p. 185-193, 2018.

    Open access
  • Alison, Lauriane; Demirörs, Ahmet F; Tervoort, Elena; Teleki, Alexandra et al.

    Emulsions Stabilized by Chitosan-Modified Silica Nanoparticles: pH Control of Structure-Property Relations

    Part of Langmuir, p. 6147-6160, 2018.

  • Tsume, Yasuhiro; Patel, Sanjaykumar; Fotaki, Nikoletta; Bergström, Christel et al.

    In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance

    Part of AAPS Journal, 2018.

  • Alskär, Linda C.; Keemink, Janneke; Johannesson, Jenny; Porter, Christopher J H et al.

    Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations

    Part of Molecular Pharmaceutics, p. 4733-4744, 2018.

  • Treyer, Andrea; Mateus, André; Wisniewski, Jacek R.; Boriss, Hinnerk et al.

    Intracellular Drug Bioavailability: Effect of Neutral Lipids and Phospholipids

    Part of Molecular Pharmaceutics, p. 2224-2233, 2018.

    Open access
  • Visnes, Torkild; Cazares-Korner, Armando; Hao, Wenjing; Wallner, Olov et al.

    Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

    Part of Science, p. 834-839, 2018.

  • Weiss, Frederik; Hammer, Helen S.; Klein, Kathrin; Planatscher, Hannes et al.

    Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

    Part of Drug Metabolism And Disposition, p. 387-396, 2018.

    Open access
  • Karlgren, Maria; Simoff, Ivailo; Keiser, M.; Oswald, S. et al.

    CRISPR-Cas9: A New Addition to the Drug Metabolism and Disposition Tool Box

    Part of Drug Metabolism And Disposition, p. 1776-1786, 2018.

  • Alvebratt, Caroline; Cheung, Ocean; Strömme, Maria; Bergström, Christel A. S.

    A Modified In Situ Method to Determine Release from a Complex Drug Carrier in Particle-Rich Suspensions

    Part of AAPS PharmSciTech, p. 2859-2865, 2018.

    Open access
  • Yang, Jiaojiao; Alvebratt, Caroline; Lu, Xi; Bergström, Christel et al.

    Amorphous Magnesium Carbonate Nanoparticles with Strong Stabilizing Capability for Amorphous Ibuprofen

    Part of International Journal of Pharmaceutics, p. 515-521, 2018.

  • Keemink, Janneke; Bergström, Christel

    Caco-2 Cell Conditions Enabling Studies of Drug Absorption from Digestible Lipid-Based Formulations

    Part of Pharmaceutical research, 2018.

    Open access