Publications

  • Kabedev, Aleksei; Hossain, Md Shakhawath; Hubert, Madlen; Larsson, Per

    Molecular dynamics simulations reveal membrane interactions for poorly water-soluble drugs: impact of bile solubilization and drug aggregation

    Part of Journal of Pharmaceutical Sciences, p. 176-185, 2021.

    DOI To DiVA

    Open access

  • Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S. et al.

    Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease

    Part of Journal of Pharmaceutical Sciences, p. 239-250, 2021.

    DOI Uploaded full-text To DiVA

    Open access

  • Berg, Staffan; Krause, Julius; Björkbom, Anders; Walter, Katrin et al.

    In Vitro and In Vivo Evaluation of 3D Printed Capsules with Pressure Triggered Release Mechanism for Oral Peptide Delivery

    Part of Journal of Pharmaceutical Sciences, p. 228-238, 2021.

    DOI To DiVA

  • Kuentz, Martin; Bergström, Christel A.S.

    Synergistic Computational Modeling Approaches as Team Players in the Game of Solubility Predictions

    Part of Journal of Pharmaceutical Sciences, p. 22-34, 2021.

    DOI To DiVA

  • Matsson, Pär; Baranczewski, Pawel; Giacomini, Kathleen M.; Andersson, Tommy B. et al.

    A Tribute to Professor Per Artursson - Scientist, Explorer, Mentor, Innovator, and Giant in Pharmaceutical Research

    Part of Journal of Pharmaceutical Sciences, p. 2-11, 2021.

    DOI To DiVA

  • Wegler, Christine; Ölander, Magnus; Lundquist, Patrik; Artursson, Per

    Global variability analysis of mRNA and protein concentrations across and within human tissues

    Part of NAR genomics and bioinformatics, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K. et al.

    A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity

    Part of Drug Metabolism And Disposition, p. 8-17, 2020.

    DOI To DiVA

  • Mudie, Deanna M.; Samiei, Nasim; Marshall, Derrick J.; Amidon, Gregory E. et al.

    Selection of In Vivo Predictive Dissolution Media Using Drug Substance and Physiological Properties

    Part of AAPS Journal, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin et al.

    Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

    Part of Nature Communications, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena et al.

    Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

    Part of Molecular Pharmaceutics, p. 1458-1469, 2020.

    DOI To DiVA

  • Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo et al.

    Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions

    Part of Pharmaceutics, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Soukarieh, Fadi; Liu, Ruiling; Romero, Manuel; Roberston, Shaun N. et al.

    Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa

    Part of Frontiers in Chemistry, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Hedge, Oliver; Bergström, Christel A. S.

    Suitability of Artificial Membranes in Lipolysis-Permeation Assays of Oral Lipid-Based Formulations

    Part of Pharmaceutical research, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Teleki, Alexandra; Nylander, Olivia; Bergström, Christel

    Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

    Part of Pharmaceutics, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Ölander, Magnus; Wisniewski, Jacek R.; Artursson, Per

    Cell-type-resolved proteomic analysis of the human liver

    Part of Liver international (Print), p. 1770-1780, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Larsson, Per; Kneiszl, Rosita C.; Marklund, Erik

    MkVsites: A tool for creating GROMACS virtual sites parameters to increase performance in all-atom molecular dynamics simulations.

    Part of Journal of Computational Chemistry, p. 1564-1569, 2020.

    DOI To DiVA

  • Bergström, Christel; Llinas, Antonio

    Strategies of solubility enhancement and perspectives in solubility measurements of pharmaceutical compounds

    Part of ADMET & DMPK, p. 176-179, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay et al.

    Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.

    Part of Journal of Pharmaceutical Sciences, 2020.

    DOI To DiVA

  • El Sayed, Mira; Alhalaweh, Amjad; Bergström, Christel A. S.

    Insights into Dissolution and Solution Chemistry of Multidrug Formulations of Antihypertensive Drugs

    Part of Molecular Pharmaceutics, p. 4018-4028, 2020.

    DOI To DiVA

  • Alvebratt, Caroline; Dening, Tahnee J; Åhlén, Michelle; Cheung, Ocean et al.

    In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier

    Part of Pharmaceutics, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Alvebratt, Caroline; Keemink, Janneke; Edueng, Khadijah; Cheung, Ocean et al.

    An in vitro dissolution–digestion–permeation assay for the study of advanced drug delivery systems

    Part of European journal of pharmaceutics and biopharmaceutics, p. 21-29, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Sou, Tomás; Soukarieh, Fadi; Williams, Paul; Stocks, Michael J. et al.

    Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions

    Part of ACS Omega, p. 25733-25746, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Hossain, Shakhawath; Joyce, Paul; Parrow, Albin; Jõemetsa, Silver et al.

    Influence of Bile Composition on Membrane Incorporation of Transient Permeability Enhancers

    Part of Molecular Pharmaceutics, p. 4226-4240, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Parrow, Albin; Larsson, Per; Augustijns, Patrick; Bergström, Christel A. S.

    Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization

    Part of Molecular Pharmaceutics, p. 3837-3844, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Joyce, Paul; Jõemetsa, Silver; Isaksson, Simon; Hossain, Shakhawath et al.

    TIRF Microscopy‐Based Monitoring of Drug Permeation Across a Lipid Membrane Supported on Mesoporous Silica

    Part of Angewandte Chemie International Edition, 2020.

    DOI Uploaded full-text To DiVA

    Open access

  • Di, Li; Artursson, Per; Avdeef, Alex; Benet, Leslie Z et al.

    The Critical Role of Passive Permeability in Designing Successful Drugs

    Part of ChemMedChem, 2020.

    DOI To DiVA

  • Wegler, Christine; Prieto Garcia, Luna; Klinting, Signe; Robertsen, Ida et al.

    Proteomics‐Informed Prediction of Rosuvastatin Plasma Profiles in Patients with a Wide Range of Body Weight

    Part of Clinical Pharmacology and Therapeutics, 2020.

    DOI To DiVA

  • Artursson, Per; Lundquist, Patrik

    A new opening for orally taken peptide drugs

    Part of Nature Biomedical Engineering, p. 12-13, 2020.

    DOI To DiVA

  • Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel et al.

    Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

    Part of Journal of Pharmaceutical Sciences, p. 630-640, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Alhalaweh, Amjad; Alzghoul, Ahmad; Bergström, Christel A. S.

    Molecular Drivers of Crystallization Kinetics for Drugs in Supersaturated Aqueous Solutions

    Part of Journal of Pharmaceutical Sciences, p. 252-259, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Nies, A. T.; Handin, Niklas; Schaeffeler, E.; Haag, M. et al.

    Comprehensive drug uptake transporter proteomics and metabolomic profiling of human liver

    Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. S8-S8, 2019.

    DOI To DiVA

  • Amidon, Gregory E.; Anderson, Bradley D.; Balthasar, Joseph P.; Bergström, Christel A.S. et al.

    Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

    Part of Journal of Pharmaceutical Sciences, p. 2-7, 2019.

    DOI To DiVA

  • Artursson, Per

    Experimental approaches to understand intracellular based drug bioavailability

    Part of Drug Metabolism and Pharmacokinetics, p. S3-S3, 2019.

    DOI To DiVA

  • Filppula, Anne M.; Parvizi, Rezvan; Mateus, André; Baranczewski, Pawel et al.

    Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations

    Part of Scientific Reports, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Keemink, Janneke; Martensson, Elin; Bergström, Christel

    Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro

    Part of Molecular Pharmaceutics, p. 921-930, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

    A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

    Part of Archives of Toxicology, p. 819-829, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Bergström, Christel A.S.; Avdeef, Alex

    Perspectives in solubility measurement and interpretation

    Part of ADMET AND DMPK, p. 88 88-105 105, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Ölander, Magnus; Handin, Niklas; Artursson, Per

    Image-based quantification of cell debris as a measure of apoptosis

    Part of Analytical Chemistry, p. 5548-5552, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Bergström, Christel; Box, Karl; Holm, Rene; Matthews, Wayne et al.

    Biorelevant intrinsic dissolution profiling in early drug development: Fundamental, methodological, and industrial aspects

    Part of European journal of pharmaceutics and biopharmaceutics, p. 101-114, 2019.

    DOI To DiVA

  • Wisniewski, Jacek R.; Wegler, Christine; Artursson, Per

    Multiple-Enzyme-Digestion Strategy Improves Accuracy and Sensitivity of Label- and Standard-Free Absolute Quantification to a Level That Is Achievable by Analysis with Stable Isotope-Labeled Standard Spiking

    Part of Journal of Proteome Research, p. 217-224, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Treyer, Andrea; Ullah, Mohammed; Parrott, Neil; Molitor, Birgit et al.

    Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

    Part of AAPS Journal, 2019.

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    Open access

  • Charalabidis, Aggelos; Sfouni, Maria; Bergström, Christel; Macheras, Panos

    The Biopharmaceutics Classification System (BCS) and the Biopharmaceutics Drug Disposition Classification System (BDDCS): Beyond guidelines

    Part of International Journal of Pharmaceutics, p. 264-281, 2019.

    DOI To DiVA

  • Keemink, Janneke; Sjögren, Erik; Holm, Rene; Bergström, Christel A. S.

    Does the Intake of Ethanol Affect Oral Absorption of Poorly Soluble Drugs?

    Part of Journal of Pharmaceutical Sciences, p. 1765-1771, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Boyd, Ben J.; Bergström, Christel; Vinarov, Zahari; Kuentz, Martin et al.

    Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems

    Part of European Journal of Pharmaceutical Sciences, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Edueng, Khadijah; Mahlin, Denny; Gråsjö, Johan; Nylander, Olivia et al.

    Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage

    Part of Molecules, 2019.

    DOI Uploaded full-text To DiVA

    Open access

  • Alvebratt, Caroline; Denning, T.; Prestidge, Cliff; Bergström, Christel et al.

    Advanced methodologies to study in vitro digestion of a lipid-loaded mesoporous drug carrier

    Part of Preclinical Form and Formulation for Drug Discovery, Gordon Research Conference 2019, 2019.

    To DiVA

  • Edueng, Khadijah; Bergström, Christel; Gråsjö, Johan; Mahlin, Denny

    Long-term physical (in)stability of spray-dried amorphous drugs: relationship with glass-forming ability and physicochemical properties

    Part of Pharmaceutics, 2019.

    DOI To DiVA

  • Prasad, Bhagwat; Achour, Brahim; Artursson, Per; Hop, Cornelis E. C. A. et al.

    Toward a Consensus on Applying Quantitative Liquid Chromatography-Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

    Part of Clinical Pharmacology and Therapeutics, p. 525-543, 2019.

    DOI To DiVA

  • Antonescu, Irina E; Rasmussen, Karina F; Neuhoff, Sibylle; Fretté, Xavier et al.

    The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach

    Part of Molecular Pharmaceutics, p. 4636-4650, 2019.

    DOI To DiVA

  • Treyer, Andrea; Walday, Sandra; Boriss, Hinnerk; Matsson, Pär et al.

    A Cell-Free Approach Based on Phospholipid Characterization for Determination of the Cell Specific Unbound Drug Fraction (f(u,cell))

    Part of Pharmaceutical research, 2019.

    DOI Uploaded full-text To DiVA

    Open access
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