- 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development postponed to January 2022
- 16.68 million to research at the pharmaceutical faculty.
- Professor Per Artursson: Giant of Pharmaceutical Sciences
- PhD-student position for project regarding the impact of drug exposure in the human colon
- Maria Karlgren receives the 2020 IQ Consortium and AAALAC International Global 3Rs Award
Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria
Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
Wegler, Christine; Matsson, Pär; Krogstad, Veronica; Urdzik, Jozef; Christensen, Hege; Andersson, Tommy B; Artursson, Per
Influence of Proteome Profiles and Intracellular Drug Exposure on Differences in CYP Activity in Donor-Matched Human Liver Microsomes and Hepatocytes
Asad, Shno; Wegler, Christine; Ahl, David; Bergström, Christel A. S.; Phillipson, Mia; Artursson, Per; Teleki, Alexandra
Proteomics-Informed Identification of Luminal Targets For In Situ Diagnosis of Inflammatory Bowel Disease
We aim to understand drug absorption and disposition at the molecular and cellular level in order to deliver drugs more effectively. We also focus on the distribution and function of important drug-transporting proteins in the human body to understand drug disposition and drug-drug interactions better.
We take a multidisciplinary approach and combine computational chemistry and bioinformatics with cell- and molecular biology, omics, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict drug absorption and delivery, to define rate-limiting barriers to the absorption and organ and cellular distribution of different types of drugs and to characterize drug transport routes across organ barriers in important pharmacokinetic organs such as the intestine, liver and kidney. Our research has provided insights into new mechanisms for drug absorption, exposure, disposition and delivery, and suggested new therapeutic strategies for efficient drug delivery.
It has also evolved to the National and European resource UDOPP (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform) which supports academic and industrial discovery projects with absorption, distribution, metabolism and excretion (ADME) as well as physicochemical profiling of compound libraries, hits and leads, and pharmacokinetic and dynamic modelling prior to preclinical and clinical studies.