- ***SAVE THE DATE*** 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022
- 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development postponed to January 2022
- 16.68 million to research at the pharmaceutical faculty.
- Professor Per Artursson: Giant of Pharmaceutical Sciences
Kundu, Snehangshu; Ali, Muhammad Akhtar; Handin, Niklas; Conway, Louis P.; Rendo, Verónica; Artursson, Per; He, Liqun; Globisch, Daniel; Sjöblom, Tobias
Common and mutation specific phenotypes of KRAS and BRAF mutations in colorectal cancer cells revealed by integrative -omics analysis
Vinarov, Zahari; Abrahamsson, Bertil; Artursson, Per; Batchelor, Hannah; Berben, Philippe; Bernkop-Schnürch, Andreas; Butler, James; Ceulemans, Jens; Davies, Nigel; Dupont, Didier; Flaten, Gøril Eide; Fotaki, Nikoletta; Griffin, Brendan T.; Jannin, Vincent; Keemink, Janneke; Kesisoglou, Filippos; Koziolek, Mirko; Kuentz, Martin; Mackie, Alan; Meléndez-Martínez, Antonio J.; McAllister, Mark; Müllertz, Anette; O'Driscoll, Caitriona M.; Parrott, Neil; Paszkowska, Jadwiga; Pavek, Petr; Porter, Christopher J. H.; Reppas, Christos; Stillhart, Cordula; Sugano, Kiyohiko; Toader, Elena; Valentová, Katerina; Vertzoni, Maria; De Wildt, Saskia N.; Wilson, Clive G.; Augustijns, Patrick
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Wegler, Christine; Gazit, Meryem; Issa, Karolina; Subramaniam, Sujay; Artursson, Per; Karlgren, Maria
Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1
We aim to understand drug absorption and disposition at the molecular and cellular level in order to deliver drugs more effectively. We also focus on the distribution and function of important drug-transporting proteins in the human body to understand drug disposition and drug-drug interactions better.
We take a multidisciplinary approach and combine computational chemistry and bioinformatics with cell- and molecular biology, omics, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict drug absorption and delivery, to define rate-limiting barriers to the absorption and organ and cellular distribution of different types of drugs and to characterize drug transport routes across organ barriers in important pharmacokinetic organs such as the intestine, liver and kidney. Our research has provided insights into new mechanisms for drug absorption, exposure, disposition and delivery, and suggested new therapeutic strategies for efficient drug delivery.
It has also evolved to the National and European resource UDOPP (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform) which supports academic and industrial discovery projects with absorption, distribution, metabolism and excretion (ADME) as well as physicochemical profiling of compound libraries, hits and leads, and pharmacokinetic and dynamic modelling prior to preclinical and clinical studies.