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Krogstad, Veronica; Peric, Alexandra; Robertsen, Ida; Kringen, Marianne K.; Wegler, Christine; Angeles, Philip Carlo; Hjelmesaeth, Jöran; Karlsson, Cecilia; Andersson, Shalini; Artursson, Per; Åsberg, Anders; Andersson, Tommy B.; Christensen, Hege
A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity
Antonescu, Irina E.; Karlgren, Maria; Pedersen, Maria L.; Simoff, Ivailo; Bergström, Christel; Neuhoff, Sibylle; Artursson, Per; Steffansen, Bente; Nielsen, Carsten Uhd
Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions
Rendo, Verónica; Stoimenov, Ivaylo; Mateus, André; Sjöberg, Elin; Svensson, Richard; Gustavsson, Anna-Lena; Johansson, Lars; Ng, Adrian; O'Brien, Casey; Giannakis, Marios; Artursson, Per; Nygren, Peter; Cheong, Ian; Sjöblom, Tobias
Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
We aim to understand drug absorption and disposition at the molecular and cellular level in order to deliver drugs more effectively. We also focus on the distribution and function of important drug-transporting proteins in the human body to understand drug disposition and drug-drug interactions better.
We take a multidisciplinary approach and combine computational chemistry and bioinformatics with cell- and molecular biology, omics, biopharmaceutics, pharmaceutics and physical chemistry to find new ways to predict drug absorption and delivery, to define rate-limiting barriers to the absorption and organ and cellular distribution of different types of drugs and to characterize drug transport routes across organ barriers in important pharmacokinetic organs such as the intestine, liver and kidney. Our research has provided insights into new mechanisms for drug absorption, exposure, disposition and delivery, and suggested new therapeutic strategies for efficient drug delivery.
It has also evolved to the National and European resource UDOPP (Uppsala University Drug Optimization and Pharmaceutical Profiling Platform) which supports academic and industrial discovery projects with absorption, distribution, metabolism and excretion (ADME) as well as physicochemical profiling of compound libraries, hits and leads, and pharmacokinetic and dynamic modelling prior to preclinical and clinical studies.