- Now hiring: PhD student for project on oral delivery of antibiotics
- Now hiring: Researcher in molecular pharmaceutics
- Now hiring: Post-doc for project about lipid nanoparticles for oral drug delivery
- Drug Delivery Group paper highlighted in J Pharm Sci's "Most Original and Most Significant Scientific Findings"
- Summary of the completed "Intestinanos" project published on CORDIS
Hedge, Oliver; Höök, Fredrik; Joyce, Paul; Bergström, Christel
Investigation of Self-Emulsifying Drug-Delivery System Interaction with a Biomimetic Membrane under Conditions Relevant to the Small Intestine
Keemink, Janneke; Hedge, Oliver; Bianco, Valentina; Hubert, Madlen; Bergström, Christel
Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay
Hempel, Nele-Johanna; Merkl, Padryk; Knopp, Matthias Manne; Berthelsen, Ragna; Teleki, Alexandra; Hansen, Anders Kragh; Sotiriou, Georgios A.; Löbmann, Korbinian
The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In Situ Amorphization
We have a strong interest in understanding the molecular reasons resulting in a poor aqueous solubility and have established tools for computational pharmaceutics that guide the formulation scientists in successful development pathways for a particular compound. We are currently developing a virtual intestine to enable evaluation optimization of new dosage forms in the computer rather than making use of lengthy experiments or animal studies.
Our research in the field of poorly soluble compounds is extensively based on drug dissolution & permeation studies to predict e.g. intestinal solubility. The research team also focuses on the development of sophisticated dosage forms that transforms problematic compounds (poorly soluble, biologics) into well-functioning oral medications.
Enabling formulations making use of lipid-based formulations, amorphous materials, mesoporous carriers and functionalized drug carriers are currently being explored. Additive manufacturing and 3D printing to produce personalized medicines to improve treatment and quality of life of severely sick children is one of our main targets.