Advanced Drug Delivery Systems & Computational Pharmaceutics
Our long term goal is to establish computational pharmaceutics as a natural step during drug development and design of advanced drug delivery systems. Read more »
News
- ***SAVE THE DATE*** 11th Symposium on Pharmaceutical Profiling in Drug Discovery and Development on January 27, 2022
- Now hiring: PhD student for project on oral delivery of antibiotics
- Now hiring: Researcher in molecular pharmaceutics
- Now hiring: Post-doc for project about lipid nanoparticles for oral drug delivery
Calendar
- Unfortunately there are no upcoming events at this time
Latest Publications
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Soukarieh, Fadi; Mashabi, Alaa; Richardson, William; Oton, Eduard Vico; Romero, Manuel; Roberston, Shaun N.; Grossman, Scott; Sou, Tomas; Liu, Ruiling; Halliday, Nigel; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Bergström, Christel; Kellam, Barrie; Emsley, Jonas; Heeb, Stephan; Williams, Paul; Stocks, Michael J.; Camara, Miguel
Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa
2021
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Teleki, Alexandra; Artursson, Per
Getting a grip with kirigami
2021
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Keemink, Janneke; Hedge, Oliver; Bianco, Valentina; Hubert, Madlen; Bergström, Christel
Comparison of cellular monolayers and an artificial membrane as absorptive membranes in the in vitro lipolysis-permeation assay
2021
OUR RESEARCH
We have a strong interest in understanding the molecular reasons resulting in a poor aqueous solubility and have established tools for computational pharmaceutics that guide the formulation scientists in successful development pathways for a particular compound. We are currently developing a virtual intestine to enable evaluation optimization of new dosage forms in the computer rather than making use of lengthy experiments or animal studies.
Our research in the field of poorly soluble compounds is extensively based on drug dissolution & permeation studies to predict e.g. intestinal solubility. The research team also focuses on the development of sophisticated dosage forms that transforms problematic compounds (poorly soluble, biologics) into well-functioning oral medications.
Enabling formulations making use of lipid-based formulations, amorphous materials, mesoporous carriers and functionalized drug carriers are currently being explored. Additive manufacturing and 3D printing to produce personalized medicines to improve treatment and quality of life of severely sick children is one of our main targets.