The Bergström research group

The Bergström group

Christel Bergström

Christel Bergström

As a drug delivery scientist, I make use of knowledge of physiological pathways to improve delivery of pharmacologically active compounds to the site of action. With a strong background in pharmaceutics, material sciences, physical chemistry and physiology, I focus on making use of the right tech with a clinical translation in mind from day one. I work multidisciplinary and make use of advanced computational modelling, develop novel in vitro tools and design new type(s) of drug carriers in my quest for personalized medicines transforming the current healthcare.

 Christel.Bergstrom@farmaci.uu.se

Brief biography
Dr Bergström is Associate Professor in Pharmaceutics at Uppsala University where she is heading a research group of ~20 people focusing on delivery of problematic compounds (poorly solubles, biologics). She is in the steering committee of the Swedish Drug Delivery Forum where she also leads the Oral Drug Delivery Platform with drug delivery to the colon and intestinal absorption of biologics being in focus.

Dr Bergström has attracted funding to her research program from highly competitive sources, including the European Research Council, Swedish Research Council, the National Institute of Health and the Swedish Foundation for Strategic Research. In 2010, Dr Bergström was awarded a Marie Curie International Qualification grant for a research program together with Monash Institute of Pharmaceutical Sciences (Australia). When returning back to Uppsala University in 2012 she was appointed adjunct associate professor at Monash University - a position she holds since then.

Dr Bergström is the cofounder of Center of Pharmaceutical Informatics at Uppsala University (now UDOPP) together with Prof Per Artursson and has in this role interacted with numerous national and international pharma and biotech companies. She is a cofounder of the Nordic Pharma Network and an EXCO member of a recently awarded NordForsk grant for a Nordic University Hub within patient-oriented products (the Nordic POP inititative). She is also an EXCO member of the Globalization Pharmaceutics Education Network. In 2017, she was elected Deputy Dean of collaboration (Medicine and Pharmacy) at Uppsala University.

Alexandra Teleki

My research interests focus on functional nanomaterial-based formulations for drug delivery and biosensing, as well as on dissolution rate of poorly-soluble compounds from controlled suspensions.

alexandra.teleki@farmaci.uu.se

Per Larsson

My research interests focus on computational modeling of biological drugs, in particular peptides, and their interactions with lipid bilayers and permeation enhancers. I also work on modeling different drug delivery systems to understand how they modulate drug solubility and dissolution.

per.larsson@farmaci.uu.se

Researchers

Madlen Hubert

I am exploring lipid-based nanoparticles for oral delivery of challenging biopharmaceuticals. I am particularly interested in studying the interactions of nanoparticle with membranes using a combination of cell-based assays, biophysical approaches as well as advanced microscopy techniques

madlen.hubert@farmaci.uu.se

Post-doctoral researchers

Aleksei Kabedev

Development of MD simulation protocols applicable to complex and lipid-rich water-based systems, and a subsequent study on drug solubilization in fasted and fed state intestinal fluids. Multicomponent systems consisting of phospholipids, bile salts, excipients and food components are of a specific interest. 

aleksei.kabedev@farmaci.uu.se

Jamal Khan

My work involves developing personalized medicines for children suffering from severe diseases. The project will explore using combinations of mesoporous materials, lipid-based formulations and 3D printing technologies to design customized oral drug delivery systems for young patients. 

jamal.khan@farmaci.uu.se

Shakhawath Hossain

The aim of my research is to improve the understanding of oral absorption of biologics using in silico modelling techniques e.g. molecular dynamics. Much of the research focus is to explore the interaction of transient permeability enhancers with different components of intestinal fluids and cellular transport mechanism of biologics with or without permeability enhancers. 

shakhawath.hossain@farmaci.uu.se

PHD STUDENTS

Albin Parrow

Exploring the role of colloidal structures in intestinal fluids. Utilizing experimental and computational techniques to understand how these structures influence solubility of poorly water soluble drugs. 

albin.parrow@farmaci.uu.se

Caroline Alvebratt

My work focus on improving the bioavailability of poorly water soluble drugs by making use of a mesoporous magnesium carbonate (Upsalite®) as an excipient in novel drug delivery systems. The compatibility of Upsalite® and other commonly used excipients will be investigated in terms of performance, physiochemical interactions and the intermolecular forces involved. 

caroline.alvebratt@farmaci.uu.se

Jenny Johannesson

My research focus on design and development of suitable oral dosage forms for children suffering from severe diseases. The work involves understanding of formulation aspects important for design of child-friendly dosage forms along with exploring 3D printing and its application for printing of lipid-based drug delivery systems to develop personalized medicines.

jenny.johannesson@farmaci.uu.se

Mira El Sayed

My research work focuses on developing a science based approach to better understand the dissolution/release and absorption from complex ASDs (amorphous solid dispersions) of multi-drug formulations with the overall goal to efficiently translate drug discovery findings to well-functioning drug products.

mira.el-sayed@farmaci.uu.se

Oliver Hedge

My research interests revolve around enhancement of intestinal absorption of poorly water soluble drugs via lipid based formulation. The main focus is increased mechanistic understanding of intestinal drug solubilization, disposition and absorption by developing and using in vitro and in silico models and simulations.

oliver.hedge@farmaci.uu.se

Rosita Kneiszl

My aim is to study the membrane permeability of peptides by using computational methods such as molecular dynamics simulations.

rosita.kneiszl@farmaci.uu.se

Shaquib Ansari

I graduated from the University of Copenhagen with an MSc in Pharmaceutical Sciences and have experience working with liposomal vaccines for intra-pulmonary delivery. My current research goal as a PhD student is to develop therapeutic magnetic nanoparticles for the treatment of IBD and to facilitate non-invasive local delivery of these nano-enabled systems.

shaquib.rahman@farmaci.uu.se

Shno Asad

I graduated with a Master’s degree in pharmacy and chemistry from the University of Gothenburg in January 2019. My current work aims to develop a new strategy to diagnose and treat inflammatory bowel disease (IBD) using functional nanomaterials. By creating an oral vehicle that incorporates magnetic nanoparticles, we aim to establish a noninvasive diagnostic approach, as well as to deliver therapeutics in a localized manner for a more efficient and targeted treatment.

shno.asad@farmaci.uu.se

Staffan Berg

I’m studying the intestinal absorption of poorly permeable compounds and the use of permeation enhancers.

staffan.berg@farmaci.uu.se

Vicky Barmpatsalou

The aim of my PhD project is to provide novel insights regarding the nature of the gastrointestinal mucus, with an end goal to develop in vitro models that will enable the assessment of the permeation behavior of poorly soluble drugs through the colonic mucus.

vicky.barmpatsalou@farmaci.uu.se