Recent publications

  • Wellhagen, Gustaf J.; Karlsson, Mats O.; Kjellsson, Maria C.

    Comparison of Precision and Accuracy of Five Methods to Analyse Total Score Data

    Part of AAPS Journal, 2021.

    Open access
  • Germovsek, Eva; Hansson, Anna; Karlsson, Mats O.; Westin, Ake et al.

    A Time-to-Event Model Relating Integrated Craving to Risk of Smoking Relapse Across Different Nicotine Replacement Therapy Formulations

    Part of Clinical Pharmacology and Therapeutics, p. 416-423, 2021.

    Open access
  • Sharan, Satish; Fang, Lanyan; Lukacova, Viera; Chen, Xiaomei et al.

    Model-Informed Drug Development for Long-Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium

    Part of Clinical Pharmacology in Drug Development, p. 220-228, 2021.

  • Rayner, Craig R.; Smith, Patrick F.; Andes, David; Andrews, Kayla et al.

    Model-Informed Drug Development for Anti-Infectives: State of the Art and Future

    Part of Clinical Pharmacology and Therapeutics, p. 867-891, 2021.

    Open access
  • Daitch, Vered; Paul, Mical; Daikos, George L.; Durante-Mangoni, Emanuele et al.

    Excluded versus included patients in a randomized controlled trial of infections caused by carbapenem-resistant Gram-negative bacteria: relevance to external validity

    Part of BMC Infectious Diseases, 2021.

    Open access
  • Friberg, Lena

    Pivotal Role of Translation in Anti-Infective Development

    Part of Clinical Pharmacology and Therapeutics, p. 856-866, 2021.

    Open access
  • Bue, Mats; Sou, Tomás; Okkels, Anna S. L.; Hanberg, Pelle et al.

    Population pharmacokinetics of piperacillin in plasma and subcutaneous tissue in patients on continuous renal replacement therapy

    Part of International Journal of Infectious Diseases, p. 133-140, 2020.

    Open access
  • Thorsted, Anders; Tano, Eva; Kaivonen, Kia; Sjölin, Jan et al.

    Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.

    Part of Antimicrobial Agents and Chemotherapy, 2020.

    Open access
  • Centanni, Maddalena; Friberg, Lena

    Model-Based Biomarker Selection for Dose Individualization of Tyrosine-Kinase Inhibitors

    Part of Frontiers in Pharmacology, 2020.

    Open access
  • Faraj, Alan; Svensson, Robin J.; Diacon, Andreas H.; Simonsson, Ulrika S H

    Drug Effect of Clofazimine on Persisters Explains an Unexpected Increase in Bacterial Load in Patients

    Part of Antimicrobial Agents and Chemotherapy, 2020.

    Open access
  • Sou, Tomás; Kukavica-Ibrulj, Irena; Levesque, Roger C.; Friberg, Lena et al.

    Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections

    Part of Molecular Pharmaceutics, p. 1458-1469, 2020.

  • Olsson, Anna; Wistrand-Yuen, Pikkei; Nielsen, Elisabet I.; Friberg, Lena et al.

    Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

    Part of Antimicrobial Agents and Chemotherapy, 2020.

    Open access
  • Van Wijk, Rob C; Ayoun Alsoud, Rami; Lennernäs, Hans; Simonsson, Ulrika S H

    Model-informed drug discovery and development strategy for the rapid development of anti-tuberculosis drug combinations

    Part of Applied Sciences, 2020.

    Open access
  • Keutzer, Lina; Simonsson, Ulrika S. H.

    Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing: Using Rifampicin as an Example

    Part of Frontiers in Pharmacology, 2020.

    Open access
  • Klastrup, Vibeke; Thorsted, Anders; Storgaard, Merete; Christensen, Steffen et al.

    Population Pharmacokinetics of Piperacillin following Continuous Infusion in Critically Ill Patients and Impact of Renal Function on Target Attainment

    Part of Antimicrobial Agents and Chemotherapy, 2020.

  • Lyauk, Yassine Kamal; Lund, Trine Meldgaard; Hooker, Andrew C.; Karlsson, Mats O. et al.

    Integrated Item Response Theory Modeling of Multiple Patient-Reported Outcomes Assessing Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia

    Part of AAPS Journal, 2020.

    Open access
  • Friberg, Lena; Guedj, J.

    Acute bacterial or viral infection-What's the difference?: A perspective from PKPD modellers

    Part of Clinical Microbiology and Infection, p. 1133-1136, 2020.

  • Nutman, Amir; Lellouche, Jonathan; Temkin, Elizabeth; Daikos, George et al.

    Colistin plus meropenem for carbapenem-resistant Gram-negative infections: in vitro synergism is not associated with better clinical outcomes

    Part of Clinical Microbiology and Infection, p. 1185-1191, 2020.

  • Tängdén, Thomas; Lundberg, Carina Vingsbo; Friberg, Lena; Huttner, Angela

    How preclinical infection models help define antibiotic doses in the clinic

    Part of International Journal of Antimicrobial Agents, p. 106008-, 2020.

    Open access
  • Gupta, Neeraj; Bottino, Dean; Simonsson, Ulrika S H; Musante, Cynthia J. et al.

    Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

    Part of Clinical Pharmacology and Therapeutics, p. 1285-1289, 2020.

  • Wistrand-Yuen, Pikkei; Olsson, Anna; Skarp, Kari Pekka; Friberg, Lena et al.

    Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

    Part of Clinical Microbiology and Infection, p. 1214-1221, 2020.

    Open access
  • Thorsted, Anders; Nielsen, Elisabet I.; Friberg, Lena

    Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

    Part of International Journal of Antimicrobial Agents, 2020.

  • Centanni, Maddalena; Krishnan, Sreenath Madathil; Friberg, Lena

    Model-based Dose Individualization of Sunitinib in Gastrointestinal Stromal Tumors

    Part of Clinical Cancer Research, p. 4590-4598, 2020.

  • Netterberg, Ida; Karlsson, Mats; Terstappen, Leon W. M. M.; Koopman, Miriam et al.

    Comparing Circulating Tumor Cell Counts with Dynamic Tumor Size Changes as Predictor of Overall Survival: A Quantitative Modeling Framework

    Part of Clinical Cancer Research, p. 4892-4900, 2020.

  • Faraj, Alan; Clewe, Oskar; Svensson, Robin J.; Mukamolova, Galina V. et al.

    Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions

    Part of Scientific Reports, 2020.

    Open access
  • Dickstein, Yaakov; Leibovici, Leonard; Carmeli, Yehuda; Daikos, George et al.

    Acinetobacter Infections: Reply to Wilson et al

    Part of Clinical Infectious Diseases, p. 1358-1359, 2020.

  • Susanto, Budi O.; Wicha, Sebastian G; Hu, Yanmin; Coates, Anthony R M et al.

    Translational Model-Informed Approach for Selection of Tuberculosis Drug Combination Regimens in Early Clinical Development.

    Part of Clinical Pharmacology and Therapeutics, p. 274-286, 2020.

    Open access
  • Netterberg, Ida; Bruno, René; Chen, Ya-Chi; Winter, Helen et al.

    The tumor time-course predicts overall survival in non-small cell lung cancer patients treated with atezolizumab: dependency on follow-up time

    Part of CPT, p. 115-123, 2020.

    Open access
  • Sou, Tomás; Hansen, Jon; Liepinsh, Edgars; Backlund, Maria et al.

    Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin.

    Part of Clinical Pharmacology and Therapeutics, 2020.

  • Becker, Katja; Aranzana-Climent, Vincent; Cao, Sha; Nilsson, Anna et al.

    Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.

    Part of Clinical Microbiology and Infection, 2020.

  • Davies Forsman, Lina; Niward, Katarina; Kuhlin, Johanna; Zheng, Xubin et al.

    Suboptimal moxifloxacin and levofloxacin drug exposure during treatment of patients with multidrug-resistant tuberculosis: results from a prospective study in China.

    Part of European Respiratory Journal, 2020.

  • Clewe, Oskar; Faraj, Alan; Hu, Yanmin; Coates, Anthony R M et al.

    A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.

    Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 421-430, 2020.

  • Van Wijk, Rob C.; van der Sar, Astrid M.; Krekels, Elke H. J.; Verboom, Theo et al.

    Quantification of Natural Growth of Two Strains of Mycobacterium Marinum for Translational Antituberculosis Drug Development

    Part of Clinical and Translational Science, p. 1060-1064, 2020.

    Open access
  • Van Wijk, Rob C.; Hu, Wanbin; Dijkema, Sharka M.; Van den Berg, Dirk-Jan et al.

    Anti‐tuberculosis effect of isoniazid scales accurately from zebrafish to humans

    Part of British Journal of Pharmacology, p. 5518-5533, 2020.

    Open access
  • Kristoffersson, Anders N.; Rognås, Viktor; Brill, Margreke JE; Dishon-Benattar, Y et al.

    Population pharmacokinetics of colistin and the relation to survival in critically ill patients infected with colistin susceptible and carbapenem-resistant bacteria

    Part of Clinical Microbiology and Infection, p. 1644-1650, 2020.

    Open access
  • Dickstein, Yaakov; Lellouche, Jonathan; Schwartz, David; Nutman, Amir et al.

    Colistin Resistance Development Following Colistin-Meropenem Combination Therapy Versus Colistin Monotherapy in Patients With Infections Caused by Carbapenem-Resistant Organisms

    Part of Clinical Infectious Diseases, p. 2599-2607, 2020.

  • Susanto, Budi Octasari; Svensson, Robin J.; Svensson, Elin M.; Aarnoutse, Rob et al.

    Rifampicin can be given as flat-dosing instead of weight-band dosing

    Part of Clinical Infectious Diseases, p. 3055-3060, 2020.

    Open access
  • Mentre, France; Friberg, Lena E.; Duffull, Stephen; French, Jonathan et al.

    Pharmacometrics and Systems Pharmacology 2030

    Part of Clinical Pharmacology and Therapeutics, p. 76-78, 2020.

  • Keutzer, Lina; Simonsson, Ulrika S. H.

    Medical Device Apps: An Introduction to Regulatory Affairs for Developers

    Part of JMIR mhealth and uhealth, 2020.

    Open access
  • Selch Larsen, Malte; Vestergaard Juul, Rasmus; Zintner, Shannon M.; Kristensen, Annemarie T. et al.

    Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene-based FVIIa prophylaxis

    Part of Haemophilia, p. 164-172, 2020.

  • Zhao, Chenyan; Wistrand-Yuen, Pikkei; Lagerbäck, Pernilla; Tängdén, Thomas et al.

    Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

    Part of International Journal of Antimicrobial Agents, 2020.

    Open access
  • Sou, Tomás; Kukavica-Ibrulj, Irena; Soukarieh, Fadi; Halliday, Nigel et al.

    Model-Based Drug Development in Pulmonary Delivery: Pharmacokinetic Analysis of Novel Drug Candidates for Treatment of Pseudomonas aeruginosa Lung Infection

    Part of Journal of Pharmaceutical Sciences, p. 630-640, 2019.

    Open access
  • Duthaler, Urs; Suenderhauf, Claudia; Karlsson, Mats O; Hussner, Janine et al.

    Population pharmacokinetics of oral ivermectin in venous plasma and dried blood spots in healthy volunteers

    Part of British Journal of Clinical Pharmacology, p. 626-633, 2019.

  • Ibrahim, Moustafa M. A.; Ueckert, Sebastian; Freiberga, Svetlana; Kjellsson, Maria C. et al.

    Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment

    Part of AAPS Journal, 2019.

    Open access
  • Ibrahim, Moustafa M. A.; Nordgren, Rikard; Kjellsson, Maria C.; Karlsson, Mats O.

    Variability Attribution for Automated Model Building

    Part of AAPS Journal, 2019.

    Open access
  • Toxopeus, Eelke L. A.; de Man, Femke M.; Krak, Nanda; Biermann, Katharina et al.

    Association between Paclitaxel Clearance and Tumor Response in Patients with Esophageal Cancer

    Part of Cancers, 2019.

    Open access
  • Germovsek, Eva; Ambery, Claire; Yang, Shuying; Beerahee, Misba et al.

    A Novel Method for Analysing Frequent Observations from Questionnaires in Order to Model Patient-Reported Outcomes: Application to EXACT (R) Daily Diary Data from COPD Patients

    Part of AAPS Journal, 2019.

    Open access
  • Arshad, Usman; Chasseloup, Estelle; Nordgren, Rikard; Karlsson, Mats O.

    Development of visual predictive checks accounting for multimodal parameter distributions in mixture models

    Part of Journal of Pharmacokinetics and Pharmacodynamics, p. 241-250, 2019.

  • Netterberg, Ida; Li, Chi-Chung; Molinero, Luciana; Budha, Nageshwar et al.

    A PK/PD Analysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab-Treated non-small Cell Lung Cancer Patients

    Part of Clinical Pharmacology and Therapeutics, p. 486-495, 2019.

  • Hermann, Robert; Litwin, Jeffrey S.; Friberg, Lena E.; Dangond, Fernando et al.

    Effects of cladribine tablets on heart rate, atrio-ventricular conduction and cardiac repolarization in patients with relapsing multiple sclerosis

    Part of British Journal of Clinical Pharmacology, p. 1484-1494, 2019.

    Open access